This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sexual dimorphism in grey vs. white matter has been demonstrated in US samples, showing females have more grey while males have more white matter. This suggests that females should have more fiber connections between cerebral hemispheres coursing through the corpus callosum (i.e., more connectivity). The research suggested here is to measure tmid-sagittal sections of the corpus callosum in different populatons, where the data allow for controlling of brain size (an algorithm from MRI, or autopsy data), age, body size (if available) and handedness. In addition, while much data from MRI studies have been based on white American subjects, little or nothing is known about other ethnic/racial populations, in particular, Black Americans, Africans, and Asians. Given a large data set, it should be possible to determine if ethnic differences are significant for either brain size or corpus callosum sexual dimorphism
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