This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is part of a thesis that is based on the assumption that dystonia is not only a basal ganglia dysfunction, but includes a higher order sensorimotor disorder leading to a modulation of parietofrontal cortical activity.
Aim of the present experiment is to investigate the cortical and subcortical activations during the performance of specific motor tasks in order to differentiate between smooth hand movement and ballistic movement with a gradual increase of stop-intervals. This healthy volunteer study aims to create a more specific hand- and finger-task for the study of dystonia patients with fMRI (as an extension of a recent study of P.M. de Vries). As dystonia is characterised by a deficit in appropriate relaxation of muscle contraction during and after purposeful movement, we were particularly interested to study the relation between the condition of interupted ballistic movements with activation in the Basal Ganglia and Supplementary Motor Areas. Specific interest goes out to these two areas because they are believed to be part of the dysfunctional activation pattern in dystonia to. Questions: Which cerebral regions are mostly activated during different task performances? Are the basal ganglia, in combination with specific cortical regions particularly involved in the ballistic movements? How are these results related to results of former studies on dystonia? The results will also serve as new reference point for further research on dystonia.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR013642-09
Application #
7369466
Study Section
Special Emphasis Panel (ZRG1-SSS-X (41))
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
9
Fiscal Year
2006
Total Cost
$5,078
Indirect Cost
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240
Dennis, Emily L; Rashid, Faisal; Faskowitz, Josh et al. (2017) MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. Proc IEEE Int Symp Biomed Imaging 2017:101-104
Walsh, Christine M; Ruoff, Leslie; Walker, Kathleen et al. (2017) Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep 40:
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809
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Levine, Andrew J; Soontornniyomkij, Virawudh; Achim, Cristian L et al. (2016) Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. J Neurovirol 22:431-41
Flournoy, John C; Pfeifer, Jennifer H; Moore, William E et al. (2016) Neural Reactivity to Emotional Faces May Mediate the Relationship Between Childhood Empathy and Adolescent Prosocial Behavior. Child Dev 87:1691-1702
Joshi, Shantanu H; Vizueta, Nathalie; Foland-Ross, Lara et al. (2016) Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 1:507-517

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