This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this Core are: 1) To assist in characterizing study participants, by providing information about gross brain morphology, with a particular emphasis on neuroanatomical abnormalities present late in the capabilities to studies requiring detailed regional neuroanatomic characterization;3) To support, with consultation;3) To support, with consultation and generation of sMRI data for pilot studies, new research initiatives employing neuroimaging techniques, such as MR Spectroscopy (MRS), MR diffusion imaging, and functional MRI (fMRI);4) To provide a liaison between HNRC investigators and two associated neuroimaging programs: (a) the Brain Image Analysis Laboratory (BIAL), a (REAP), a multi-investigator core infrastructure and training program focusing on applications of fMRI in dementing disorders (T. Jernigan, P.I.);5) To provide mentorship, consultation, and training in neuroimaging to students and junior investigators affiliated with the HNRC. The Core will support ongoing work investigating the nature and regional distribution of HIV-related brain abnormalities measurable in vivo (with sMRI data), as well as new work aimed at developing more sensitive and more efficient means of monitoring HIV-related CNS dysfunction with other neuroimaging modalities (e.g., fMRI, MR Spectroscopy, etc.). The Core will also focus on new method development targeting the specific abnormalities present in this population, including the development of: more fully automated image-analytic methods for assessment of brain structure from MRI volumes;maps of the distribution of brain tissue anomalies associated with CDC-C3 status and ultimately, with autopsy-verified HIV encephalitis (HIVE);and more sophisticated methods for characterizing prevalent MRI abnormalities in cerebral white matter.
| Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139 |
| Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240 |
| Dennis, Emily L; Rashid, Faisal; Faskowitz, Josh et al. (2017) MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. Proc IEEE Int Symp Biomed Imaging 2017:101-104 |
| Walsh, Christine M; Ruoff, Leslie; Walker, Kathleen et al. (2017) Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep 40: |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809 |
| Agis, Daniel; Goggins, Maria B; Oishi, Kumiko et al. (2016) Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale. Stroke 47:1459-65 |
| Levine, Andrew J; Soontornniyomkij, Virawudh; Achim, Cristian L et al. (2016) Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. J Neurovirol 22:431-41 |
| Flournoy, John C; Pfeifer, Jennifer H; Moore, William E et al. (2016) Neural Reactivity to Emotional Faces May Mediate the Relationship Between Childhood Empathy and Adolescent Prosocial Behavior. Child Dev 87:1691-1702 |
| Joshi, Shantanu H; Vizueta, Nathalie; Foland-Ross, Lara et al. (2016) Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 1:507-517 |
| Ordóñez, Anna E; Loeb, Frances F; Zhou, Xueping et al. (2016) Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. J Am Acad Child Adolesc Psychiatry 55:792-9 |
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