This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Comparison of protein sequences from completely sequenced genomes allows the clustering of the amino acid sequences into related families. The structures of the protein members of these sequence families will all be quite similar. While determining the structures of all proteins is an unreasonable aim, the determination of one structure from each of the largest sequence families is an attainable goal and the aim of the NIH Protein Structure Initiative. As part of the Midwest Center for Structural Genomics, we are purifying, crystallizing and determining the structures of a large number of proteins. While many of these proteins have not been functionally characterized, the large scale sequencing and structure determination efforts are going to provide extensive background information for addressing the question: What are the biological roles of these proteins? Those that have homologues in many widely divergent species must play an important role under some conditions to have been conserved.
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