This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A one day workshop titled Microdiffraction in Structural Biology was held on May 5, 2006, during the APS User Meeting. This was organized by NE-CAT Executive Committee members Steve Ealick and Steve Harrison in anticipation of implementation of microdiffraction capability during later part of 2006 at one of its beam lines. A total of 120 researchers registered for this workshop that brought together experts and users interested in this upcoming field. Speakers and topics included: Qun Shun (Advanced Photon Source (APS)) - overview of of microdiffraction activities at APS, covering a wide range of topics from material science to biological sciences. Ehmke Pohl (Swiss Light SourceSLS) - description of integration of an MD2 microdiffractometer MD2 and an Actor robotic sample changer ito beam line XO6SA. Michael Sawaya (UCLA) - example of a practical application of microdiffraction to structural biology. David Flot ( European Synchrotron Radiation Facility) - design and operation of beam line ID23-2, dedicated to macromolecular crystallography and able to produce beams less than 10 micrometer in diameter. Florent Cipriani (European Molecular Biology Laboratory/European Synchrotron Radiation Facility) - microdiffractometer MD2 hardware, software and operation and robotic sample changer SC3 and mini kappa goniometer. Kanagalaghatta Rajashankar (NE-CAT, APS) - NE-CAT's plans to implement microdiffraction. Gwyndaf Evans ( Diamond Light Source) - installation of an installing an aperture array consisting of apertures of many different sizes and shapes. Gerd Rosenbaum (Structural Biology Center, APS) - implementation of microdiffraction and installation of three undulators in a straight stretch of ID-19. Speakers from Europe and the USA discussed a wide assortment of topics including, design of synchrotron beam lines to produce micro beams, a variety disciplines that benefit from micro-beams, design and use of microdiffractometer for structural biology, examples of practical application of microdiffraction, existing facilities and future plans for microdiffraction at various synchrotron sites in the USA and Europe, and challenges in the field of microdiffraction. This workshop provided a platform for exchange of ideas and opinions on microdiffraction among the structural biology community
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