This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Connexin is one of the members of the family of gap junction proteins. It is a transmembrane channel and mutations in this protein causes deafness Our goal is to obtain a high resolution structure of this membrane channel using cryo electron microscopy.
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