This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The goal of this study was to determine the structure and position of glycosylation sites on the Drosophila sialyltransferase protein, DSiaT. DSiaT represents the first characterized sialyltransferase in the protostome lineage of animals (Koles et al. 2004, JBC 279: 4346-435). This sialyltransferase is closely related to the ST6GAL family of vertebrate sialyltransferases, which indicates that DSiaT may represent the most evolutionary ancient type of matazoan sialyltransferases.
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