In this proposal three topics are addressed (1) development and application of technology to measure chemical reaction products and genetic changes directly in human blood and tissue samples (2) movement and transformation of chemicals from Superfund Sites in the Aberjona Watershed which serves as our environmental laboratory and (3) improvement and toxicological evaluation of chemical destruction technology including incineration, wet oxidation and a proposal using biological transformation of complex chemical mixtures in soils. All three research areas use the human population or the environment of the Aberjona Watershed a 25 square mile Watershed near Boston in which reside some 50,000 people. Biomedical Research Projects (4) - Development and evaluation of technology for measurement of chemical-macromolecular reaction products and mutational spectra in humans. Chemical Fate and Transport in the Environment (6) - Study of the movement of chemicals from Superfund sites through ground and surface water in the Aberjona Watershed. Degradation and Destruction of Toxic Wastes (4) - Improvement and toxicological evaluation of thermal destruction technology and novel approaches to microbial degradation of toxic chemicals. The MIT Center for Environmental Health Sciences is an inter-disciplinary unit with research programs involving faculty in Toxicology (6), Chemical Engineering (5), Civil Engineering (6), Chemistry (1) and Biology (1) as well as the Harvard School of Public Health (3). Its programmatic efforts address basic molecular mechanisms of mutagenesis by chemicals and radiation, the cascade of mutations leading to chemically induced cancer, the role of endogenous and dietary nitrite in causing human cancer, the formation and biological effects of combustion emissions, the role of background radiation in human mutation and assessment of the health effects of human exposure to chemicals emanating from chemical dump sites. (Superfund Program).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES004675-06
Application #
3104379
Study Section
Special Emphasis Panel (SRC (S2))
Project Start
1987-09-30
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Senn, David B; Gawel, James E; Jay, Jennifer A et al. (2007) Long-term fate of a pulse arsenic input to a eutrophic lake. Environ Sci Technol 41:3062-8
Diez, Sergi; Noonan, Gregory O; MacFarlane, John K et al. (2007) Ferrous iron oxidation rates in the pycnocline of a permanently stratified lake. Chemosphere 66:1561-70
Risoul, Veronique; Richter, Henning; Lafleur, Arthur L et al. (2005) Effects of temperature and soil components on emissions from pyrolysis of pyrene-contaminated soil. J Hazard Mater 126:128-40
Coller, Hilary A; Khrapko, Konstantin; Herrero-Jimenez, Pablo et al. (2005) Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium. Mutat Res 578:256-71
Pedersen, Daniel U; Durant, John L; Taghizadeh, Koli et al. (2005) Human cell mutagens in respirable airborne particles from the northeastern United States. 2. Quantification of mutagens and other organic compounds. Environ Sci Technol 39:9547-60
Durant, John L; Ivushkina, Tatiana; MacLaughlin, Kathy et al. (2004) Elevated levels of arsenic in the sediments of an urban pond: sources, distribution and water quality impacts. Water Res 38:2989-3000
Blute, Nicole Keon; Brabander, Daniel J; Hemond, Harold F et al. (2004) Arsenic sequestration by ferric iron plaque on cattail roots. Environ Sci Technol 38:6074-7
Pedersen, Daniel U; Durant, John L; Penman, Bruce W et al. (2004) Human-cell mutagens in respirable airborne particles in the northeastern United States. 1. Mutagenicity of fractionated samples. Environ Sci Technol 38:682-9
Southworth, Barbara A; Voelker, Bettina M (2003) Hydroxyl radical production via the photo-Fenton reaction in the presence of fulvic acid. Environ Sci Technol 37:1130-6
Tomita-Mitchell, Aoy; Ling, Losee Lucy; Glover, Curtis L et al. (2003) The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. Cancer Res 63:5793-8

Showing the most recent 10 out of 80 publications