Abstract

The core laboratory is the chemical analysis arm of the Center for Environmental Health Sciences. It is a central resource in analytical chemistry for Superfund project investigators, providing them with analytical expertise, training, and access to analytical instrumentation. A major CEHS goal is to foster collaborative research among engineers, genetic toxicologists, analytical chemists, and other investigators in order to solve important problems in human health effects research. The core laboratory, incorporating facilities for both organic (Core Lab in Analytical Chemistry, CL/Chem) and inorganic analysis (Instrumental Neutron Activation Analysis Facility, INAA) is an important resource in making this research collaboration come to fruition.
Specific aims : Core laboratory staff will work with projects 1, 5, 7, 8, 10, 11, and 12 to conduct organic and inorganic analysis and mutagenicity testing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES004675-09
Application #
3733689
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Senn, David B; Gawel, James E; Jay, Jennifer A et al. (2007) Long-term fate of a pulse arsenic input to a eutrophic lake. Environ Sci Technol 41:3062-8
Diez, Sergi; Noonan, Gregory O; MacFarlane, John K et al. (2007) Ferrous iron oxidation rates in the pycnocline of a permanently stratified lake. Chemosphere 66:1561-70
Risoul, Veronique; Richter, Henning; Lafleur, Arthur L et al. (2005) Effects of temperature and soil components on emissions from pyrolysis of pyrene-contaminated soil. J Hazard Mater 126:128-40
Coller, Hilary A; Khrapko, Konstantin; Herrero-Jimenez, Pablo et al. (2005) Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium. Mutat Res 578:256-71
Pedersen, Daniel U; Durant, John L; Taghizadeh, Koli et al. (2005) Human cell mutagens in respirable airborne particles from the northeastern United States. 2. Quantification of mutagens and other organic compounds. Environ Sci Technol 39:9547-60
Durant, John L; Ivushkina, Tatiana; MacLaughlin, Kathy et al. (2004) Elevated levels of arsenic in the sediments of an urban pond: sources, distribution and water quality impacts. Water Res 38:2989-3000
Blute, Nicole Keon; Brabander, Daniel J; Hemond, Harold F et al. (2004) Arsenic sequestration by ferric iron plaque on cattail roots. Environ Sci Technol 38:6074-7
Pedersen, Daniel U; Durant, John L; Penman, Bruce W et al. (2004) Human-cell mutagens in respirable airborne particles in the northeastern United States. 1. Mutagenicity of fractionated samples. Environ Sci Technol 38:682-9
Southworth, Barbara A; Voelker, Bettina M (2003) Hydroxyl radical production via the photo-Fenton reaction in the presence of fulvic acid. Environ Sci Technol 37:1130-6
Tomita-Mitchell, Aoy; Ling, Losee Lucy; Glover, Curtis L et al. (2003) The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. Cancer Res 63:5793-8

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