Abstract

Preliminary studies indicated that 2,2,4,4,5,5- HCB significantly inhibited 3,3,4,4,5-pentaCB-mediated teratogenicity and future collaborative studies will further characterize the nature of these non-additive interactions. The developmental toxicity of chlorinated phenols, which are major components of wood-preserving wastes, was investigated using a series of developmental toxicity assays, including in vivo segment II studies in rats, hydra assay, HEPM, and whole embryo culture. The effects of these compounds in primary cell culture bioassays will be carried out in future studies. Field- practical methods for the detection (minicolumn assays) and detoxification (clay minerals) of mycotoxins have been developed and patented by Dr. Phillips. The basic technologies have been licensed and commercial products are currently being used worldwide. The proposed research in this program project will further enhance this diagnostic assay for chlorophenols (CPs) and also utilize clay-based technology for the degradation of CPs and other halogenated aromatic hydrocarbons (HAHs) associated with oily and wood-preserving wastes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004917-10
Application #
6271113
Study Section
Project Start
1998-04-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Texas A&M University
Department
Type
DUNS #
047006379
City
College Station
State
TX
Country
United States
Zip Code
77845

  Publications

Phillips, Tracie D; Richardson, Molly; Cheng, Yi-Shing Lisa et al. (2015) Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89:967-77
Barhoumi, Rola; Mouneimne, Youssef; Chapkin, Robert S et al. (2014) Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells. PLoS One 9:e90908
dela Cruz, Albert Leo N; Cook, Robert L; Dellinger, Barry et al. (2014) Assessment of environmentally persistent free radicals in soils and sediments from three Superfund sites. Environ Sci Process Impacts 16:44-52
Wlodarczyk, Bogdan J; Zhu, Huiping; Finnell, Richard H (2014) Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity. Toxicol Appl Pharmacol 275:22-7
Taylor, John F; Robinson, Abraham; Mitchell, Nicole J et al. (2013) In vivo efficacy of ferrihydrite as an enterosorbent for arsenic: short-term evaluation in rodents. J Toxicol Environ Health A 76:167-75
Theodorakis, Christopher W; Bickham, John W; Donnelly, Kirby C et al. (2012) DNA damage in cichlids from an oil production facility in Guatemala. Ecotoxicology 21:496-511
Dash, Bhagirathi; Phillips, Timothy D (2012) Molecular characterization of a catalase from Hydra vulgaris. Gene 501:144-52
Barhoumi, Rola; Mouneimne, Youssef; Ramos, Ernesto et al. (2011) Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56
Kelley, Matthew A; Gillespie, Annika; Zhou, Guo-Dong et al. (2011) In situ biomonitoring of caged, juvenile Chinook salmon (Oncorhynchus tshawytscha) in the Lower Duwamish Waterway. Mar Pollut Bull 62:2520-32
Rinner, Brian P; Matson, Cole W; Islamzadeh, Arif et al. (2011) Evolutionary toxicology: contaminant-induced genetic mutations in mosquitofish from Sumgayit, Azerbaijan. Ecotoxicology 20:365-76

Showing the most recent 10 out of 268 publications