The title of this proposal captures its essence, 'Hazardous Waste Risk and Remediation in the Southwest'. The University of Arizona SBRP renewal application builds on the achievements of the previous grant. The theme of this Program is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and through development of innovative remediation technologies. The application emphasizes hazardous waste issues in the Southwestern U.S. (and Mexican Border) due to the unique arid nature of this environment. However, the results of the studies are not limited to the Southwest since the main toxicants being examined, As and halogenated hydrocarbons, are ubiquitous throughout developed countries. The Program consists of 10 research projects-five biomedical projects and five environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of As toxicity in target tissues, factors that affect the susceptibility of populations to As-induced toxicity, and the effects of As and TCE on organ development. The environmental sciences projects are investigating how hazardous wastes (As, TCE/perchloroethylene [PCE]) can be optimally characterized for remediation and innovative techniques for containing or degrading these contaminants in an arid Southwest environment. These research projects are supported by 5 cores that administer the Program, translate the results to the stakeholders, provide research services, promote unique outreach efforts to Mexico, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.
| Zeng, Chao; Nguyen, Chi; Boitano, Scott et al. (2018) Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells. Environ Res 164:452-458 |
| Zeb, Bahadar; Alam, Khan; Sorooshian, Armin et al. (2018) On the Morphology and Composition of Particulate Matter in an Urban Environment. Aerosol Air Qual Res 18:1431-1447 |
| Khan, Muhammad Amjad; Ding, Xiaodong; Khan, Sardar et al. (2018) The influence of various organic amendments on the bioavailability and plant uptake of cadmium present in mine-degraded soil. Sci Total Environ 636:810-817 |
| Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38 |
| Fu, Xiaori; Dionysiou, Dionysios D; Brusseau, Mark L et al. (2018) Enhanced effect of EDDS and hydroxylamine on Fe(II)-catalyzed SPC system for trichloroethylene degradation. Environ Sci Pollut Res Int 25:15733-15742 |
| Duncan, Candice M; Brusseau, Mark L (2018) An assessment of correlations between chlorinated VOC concentrations in tree tissue and groundwater for phytoscreening applications. Sci Total Environ 616-617:875-880 |
| Virgone, K M; Ramirez-Andreotta, M; Mainhagu, J et al. (2018) Effective integrated frameworks for assessing mining sustainability. Environ Geochem Health 40:2635-2655 |
| Namdari, Soodabeh; Karimi, Neamat; Sorooshian, Armin et al. (2018) Impacts of climate and synoptic fluctuations on dust storm activity over the Middle East. Atmos Environ (1994) 173:265-276 |
| Hossein Mardi, Ali; Khaghani, Ali; MacDonald, Alexander B et al. (2018) The Lake Urmia environmental disaster in Iran: A look at aerosol pollution. Sci Total Environ 633:42-49 |
| Dehghani, Mansooreh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of BTEX in a hot spot for urban pollution. Ecotoxicol Environ Saf 155:133-143 |
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