Lead in the environment is know to influence human exposure and to produce adverse health impact. Exposure to relatively high levels of lead has been evaluated in occupational setting, where exposed individuals have had chronic exposure, and in community settings, where inadvertent lead exposure to children has resulted in acute lead poisoning. However, the relationship relatively low environmental exposures to lead in a community setting are not well characterized. We propose to investigate the relationship between environmental lead concentrations by using standard exposure assessment protocols and biological markers of exposure. These biological markers are two; the standard blood lead measurement, and the newer, K-XRF technique for measuring bone lead in vivo. Several longitudinal sub-studies are planned. The major focus of this investigation is the repeated simultaneous measurement of environmental lead concentrations, blood lead concentrations, and bone lead concentrations in adolescents. The target group consists of high school students who are unlikely to have received significant occupational exposure to lead. The study will start with a baseline evaluation of the cohort, including questionnaire administration, environmental sampling in the around their homes, a blood lead measurement, and a bone lead measurement. This procedure will be repeated at one year intervals. Data will be analyzed to evaluate the relationship between current environmental lead level and blood lead, environmental level and bone lead concentrations, and the longitudinal relationship between these environmental and biological lead measures. Also, we propose to examine the ability of the bone lead technique to identify those adolescents who, in early childhood, were diagnosed as lead poisoned. Through this study and the following of adolescents for a period of several years, we hope to gain new insights regarding the kinetics of lead uptake by bone during this important growth period. Finally, we will examine the relationship between the ALA-D gene polymorphism on measured blood lead and bone lead concentrations, affording new insight on the impact of this mutation on the effects associated with a given lead exposure.

Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Jansen, E C; Zhou, L; Song, P X K et al. (2018) Prenatal lead exposure in relation to age at menarche: results from a longitudinal study in Mexico City. J Dev Orig Health Dis 9:467-472
Lin, Pi-I D; Bromage, Sabri; Mostofa, Md Golam et al. (2017) Associations between Diet and Toenail Arsenic Concentration among Pregnant Women in Bangladesh: A Prospective Study. Nutrients 9:
Bashash, Morteza; Thomas, Deena; Hu, Howard et al. (2017) Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico. Environ Health Perspect 125:097017
Vieira, Verónica M; Fabian, M Patricia; Webster, Thomas F et al. (2017) Spatial Variability in ADHD-Related Behaviors Among Children Born to Mothers Residing Near the New Bedford Harbor Superfund Site. Am J Epidemiol 185:924-932
Sánchez, Brisa N; Kim, Sehee; Sammel, Mary D (2017) Estimators for longitudinal latent exposure models: examining measurement model assumptions. Stat Med 36:2048-2066
Zota, Ami R; Riederer, Anne M; Ettinger, Adrienne S et al. (2016) Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site. J Expo Sci Environ Epidemiol 26:510-9
Kile, Molly L; Faraj, Joycelyn M; Ronnenberg, Alayne G et al. (2016) A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women. BMC Public Health 16:158
Tamayo y Ortiz, Marcela; Téllez-Rojo, Martha María; Hu, Howard et al. (2016) Lead in candy consumed and blood lead levels of children living in Mexico City. Environ Res 147:497-502
Cantoral, A; Téllez-Rojo, M M; Ettinger, A S et al. (2016) Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age. Pediatr Obes 11:68-74
Kim, Daniel; Kubzansky, Laura D; Baccarelli, Andrea et al. (2016) Psychological factors and DNA methylation of genes related to immune/inflammatory system markers: the VA Normative Aging Study. BMJ Open 6:e009790

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