Abstract

The overall aims of this project are to provide more meaningful estimates of human and ecological exposure to contaminants and to evaluate evolving strategies for subsurface restoration in heterogeneous multiphase subsurface systems. These overall aims will be achieved by meeting the following specific aims: 1. to investigate the effect of subsurface heterogeneities on the formation of NAPL dissolution fingers; 2. to evaluate factors that control the formation and morphology of NAPL pools in heterogeneous subsurface systems; 3. to analyze the effect of nonequilibrium sorption/desorption processes in heterogeneous systems on subsurface restoration; 4. to evaluate NAPL-aqueous phase mass transfer, including the role of dissolution fingering, in heterogeneous porous media systems in the presence of solubilizing agents: and 5. to determine the effect of solubilizing agents on subsurface restoration of heterogeneous media contaminated with NAPL pools.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES005948-04
Application #
3733874
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Luo, Yu-Syuan; Hsieh, Nan-Hung; Soldatow, Valerie Y et al. (2018) Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Population genetic diversity in zebrafish lines. Mamm Genome 29:90-100
Luo, Yu-Syuan; Furuya, Shinji; Soldatov, Valerie Y et al. (2018) Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice. Toxicol Sci 164:489-500
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure. Environ Health Perspect 126:067010
To, Kimberly T; Fry, Rebecca C; Reif, David M (2018) Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Min 11:10
Dalaijamts, Chimeddulam; Cichocki, Joseph A; Luo, Yu-Syuan et al. (2018) Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152
Gray, Kathleen M (2018) From Content Knowledge to Community Change: A Review of Representations of Environmental Health Literacy. Int J Environ Res Public Health 15:
Li, Gen; Jima, Dereje; Wright, Fred A et al. (2018) HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 19:95
Adebambo, Oluwadamilare A; Shea, Damian; Fry, Rebecca C (2018) Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-?) pathways in placental JEG-3 trophoblast cells via reactive oxygen species. Toxicol Appl Pharmacol 342:108-115
Smeester, Lisa; Fry, Rebecca C (2018) Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic. Curr Environ Health Rep 5:134-144

Showing the most recent 10 out of 505 publications