Abstract

The overall aims of this project are to provide more meaningful estimates of human and ecological exposure to contaminants and a more complete understanding of subsurface restoration processes by using stochastic analysis of flow and transport phenomena.
Specific aims for this project are the following; 1. to extend recently developed diagrammatic techniques for the solution of fluid flow in heterogeneous porous media to three-dimensional anisotropic systems; 2. to investigate in detail the effects of realistic boundary and initial conditions on the form of solutions to the groundwater flow equation; 3. to develop a numerical algorithm based upon the space transformation method for the solution of three-dimensional fluid flow problems in heterogeneous media; 4. to adapt diagrammatic and space transformation methods developed for three-dimensional fluid flow problems in heterogeneous media to the problem of contaminant transport; 5. to develop ab initio approach for deriving macroscopic stochastic theories from fundamental underlying microscopic res presentations of flow and transport phenomena: 6. to investigate the importance of non-local flow and transport phenomena in heterogeneous media based upon an ab initio approach; 7. to extend the use of the diagrammatic and space transformation methods for the solution of non-local models of flow and transport.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES005948-06
Application #
6239623
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Gray, Kathleen M (2018) From Content Knowledge to Community Change: A Review of Representations of Environmental Health Literacy. Int J Environ Res Public Health 15:
Li, Gen; Jima, Dereje; Wright, Fred A et al. (2018) HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 19:95
Adebambo, Oluwadamilare A; Shea, Damian; Fry, Rebecca C (2018) Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-?) pathways in placental JEG-3 trophoblast cells via reactive oxygen species. Toxicol Appl Pharmacol 342:108-115
Smeester, Lisa; Fry, Rebecca C (2018) Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic. Curr Environ Health Rep 5:134-144
Luo, Yu-Syuan; Furuya, Shinji; Chiu, Weihsueh et al. (2018) Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52
Singleton, David R; Lee, Janice; Dickey, Allison N et al. (2018) Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp. nov. Syst Appl Microbiol 41:460-472
Luo, Yu-Syuan; Hsieh, Nan-Hung; Soldatow, Valerie Y et al. (2018) Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Population genetic diversity in zebrafish lines. Mamm Genome 29:90-100
Luo, Yu-Syuan; Furuya, Shinji; Soldatov, Valerie Y et al. (2018) Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice. Toxicol Sci 164:489-500
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure. Environ Health Perspect 126:067010

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