The Cornell Superfund Basic Research and Education Program (SBRBP) under NIEHS sponsorship has sought to enhance our ability to investigate, assess, remediate, and monitor the clean up of hazardous wastes. The Cornell SBREP initially addressed this mission via a comprehensive theme -- identifying and reducing hazards and chronic exposure from low-level substances from Superfund sites with regard to both human health and the environment. These studies and other experiences in the program have directed us to sharpen that theme to studies of: 'Bioavailability And impact of hazardous substances in human health and ecological risk, especially as related to exposure, neurological and immunological effects, and remediation of sites containing polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and heavy metals such as lead (Pb).' We will address this theme through studies of biological responses (developmental, immunologic and neurologic/behavioral) in which exposure can be integrated across diverse species, and biodegradation studies and chemodynamics can be integrated via interactive modeling. In addition to the core activities (administration, lab technical services, and training), the program proposes three basic biomedical project (dogs as sentinels for immunologic threats from PCBs, rats and chickens as responding to chelation therapy following Pb exposure, and rats responding to the same stressor, but evaluated with respect to cognitive deficits). A fourth basic biomedical project (immunobiosensors) will link some of the field work to both results in lab animals and wildlife and to success in describing field exposures. The companion notion is that bioavailability may be reflected in biodegradation patterns and successfully modeled as a statistical process of chemodynamic interactions. Three projects propose to examine sequestration as a matter of aging, the role of exopolymers to alter distributions of organics and then inorganics, and the development of visualization methods to characterize microscale forces and locations. Moreover, the Program proposes to provide a variety of sophisticated laboratory services while continuing a comprehensive training program including risk assessment, ethical responsibilities, and quality science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES005950-08S1
Application #
6149202
Study Section
Special Emphasis Panel (SRC (G3))
Project Start
1992-04-01
Project End
2001-03-31
Budget Start
1999-04-20
Budget End
2001-03-31
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Cornell University
Department
Other Basic Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Smith, Donald; Strupp, Barbara J (2013) The scientific basis for chelation: animal studies and lead chelation. J Med Toxicol 9:326-38
Beaudin, Stephane A; Stangle, Diane E; Smith, Donald R et al. (2007) Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats. Neurotoxicol Teratol 29:188-202
Stangle, Diane E; Smith, Donald R; Beaudin, Stephane A et al. (2007) Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect 115:201-9
Quimby, Fred W; Casey, Ann C; Arquette, Mary Fadden (2005) From dogs to frogs: how pets, laboratory animals, and wildlife aided in elucidating harmful effects arising from a hazardous dumpsite. ILAR J 46:364-9
Chen, Suping; Golemboski, Karen; Piepenbrink, Michael et al. (2004) Developmental immunotoxicity of lead in the rat: influence of maternal diet. J Toxicol Environ Health A 67:495-511
Stangle, Diane E; Strawderman, Myla S; Smith, Donald et al. (2004) Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure. Environ Health Perspect 112:302-8
Driscoll, Lori L; Carroll, Jenna C; Moon, Jisook et al. (2004) Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. Behav Neurosci 118:1196-205
Lee, Ji-Eun; Dietert, Rodney R (2003) Developmental immunotoxicity of lead: impact on thymic function. Birth Defects Res A Clin Mol Teratol 67:861-7
Savage, Wesley K; Quimby, Fred W; DeCaprio, Anthony P (2002) Lethal and sublethal effects of polychlorinated biphenyls on Rana sylvatica tadpoles. Environ Toxicol Chem 21:168-74
Tang, Jixin; Liste, Hans-Holger; Alexander, Martin (2002) Chemical assays of availability to earthworms of polycyclic aromatic hydrocarbons in soil. Chemosphere 48:35-42

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