The primary functions of the Training and Outreach Core are to: 1) provide the means by which the program project can have a positive impact on the training of environmental health scientists; and 2) facilitate the dissemination of new knowledge gained by program project research to other scientists, government agencies, industry, and the community. Several activities are proposed to fulfill these functions. The program project will foster growth in both size and scope of the existing pre- doctoral graduate program in Interdisciplinary Toxicology by providing assistantship and tuition remission support. Post-graduate education will benefit from support of post-doctoral fellows, and also through development of annual workshops on state-of-the-art techniques in studying human health and environmental impacts of contaminants. Outreach activities will take advantage of the considerable resources that exist within the University for this purpose, particularly with respect to technology transfer. Special vehicles for outreach that will be made possible by this program project are a newsletter and an annual symposium. The newsletter will contain informative articles regarding research advances arising from program project research, as well as brief reviews of pertinent topics related to effects of chlorinated compounds on human health and the environment. Dissemination of more detailed, technical information regarding research discoveries will occur in an annual symposium. While program project-related research will provide key material for this symposium, speakers and topics will also be drawn from universities, the community, state and federal government, private and public conservation groups, and the general public. The symposium will not only provide access to research results and researchers for those outside the university, it will also serve as a catalyst for the exchange of ideas on environmental problems of local, regional, and national interest. Each of the individual projects will contribute to, and benefit from the activities of the training and outreach core.

Project Start
1998-04-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Mangal, Naveen; James, Margaret O; Stacpoole, Peter W et al. (2018) Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. J Clin Pharmacol 58:212-220
Jiang, Yu; Milavetz, Gary; James, Margaret O et al. (2017) A Mechanism-Based Pharmacokinetic Enzyme Turnover Model for Dichloroacetic Acid Autoinhibition in Rats. J Pharm Sci 106:1396-1404
Shroads, Albert L; Coats, Bonnie S; Langaee, Taimour et al. (2015) Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans. Drug Metab Pers Ther 30:49-55
Shroads, A L; Coats, B S; McDonough, C W et al. (2015) Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. J Clin Pharmacol 55:50-5
James, Margaret O; Kleinow, Kevin M (2014) Seasonal influences on PCB retention and biotransformation in fish. Environ Sci Pollut Res Int 21:6324-33
Garcia-Reyero, Natàlia; Martyniuk, Christopher J; Kroll, Kevin J et al. (2013) Transcriptional signature of progesterone in the fathead minnow ovary (Pimephales promelas). Gen Comp Endocrinol 192:159-69
Kocerha, Jannet; Prucha, Melinda S; Kroll, Kevin J et al. (2010) Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways. Endocrinology 151:341-9
Tan, Xiaobing; Yim, Sun-Young; Uppu, Prasanna et al. (2010) Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate. Aquat Toxicol 99:300-8
Nyagode, Beatrice A; James, Margaret O; Kleinow, Kevin M (2009) Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108:320-9
Rauschenberger, R Heath; Sepulveda, Maria S; Wiebe, Jon J et al. (2009) Nutrient and organochlorine pesticide concentrations in American alligator eggs and their associations with clutch viability. J Aquat Anim Health 21:249-61

Showing the most recent 10 out of 98 publications