Abstract

Analysis of environmental and biological samples for toxicants associated with the specific projects outlined in this proposal will be performed by the Analytical Toxicology Core Laboratory (ATCL). This facility meets EPA requirements for the analysis of environmental toxins, as well as following Good Laboratory Practice as described by the FDA. In addition, the laboratory follows good QA/QC management practices which produce analytical data that are of high quality, that can withstand the scrutiny of technical peer review and which can support regulatory activities when needed. The laboratory presently has eleven staff with expertise in the analysis of biological samples for drugs and toxins, and is equipped with state of the art equipment including several GC-MS and two LC-MS instruments. The ATCL has the expertise and facilities to allow the quantitative analysis for all of the toxicants listed in this proposal in a range of matrices. The facility would also offer the service of analytical method development and validation should this be requirement by individual project. The laboratory will act as an interface between the environmental and health sciences and offer a unique training opportunity for graduate students.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007375-08
Application #
6580391
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$131,644
Indirect Cost

  Institution

Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Mangal, Naveen; James, Margaret O; Stacpoole, Peter W et al. (2018) Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. J Clin Pharmacol 58:212-220
Jiang, Yu; Milavetz, Gary; James, Margaret O et al. (2017) A Mechanism-Based Pharmacokinetic Enzyme Turnover Model for Dichloroacetic Acid Autoinhibition in Rats. J Pharm Sci 106:1396-1404
Shroads, Albert L; Coats, Bonnie S; Langaee, Taimour et al. (2015) Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans. Drug Metab Pers Ther 30:49-55
Shroads, A L; Coats, B S; McDonough, C W et al. (2015) Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. J Clin Pharmacol 55:50-5
James, Margaret O; Kleinow, Kevin M (2014) Seasonal influences on PCB retention and biotransformation in fish. Environ Sci Pollut Res Int 21:6324-33
Garcia-Reyero, Natàlia; Martyniuk, Christopher J; Kroll, Kevin J et al. (2013) Transcriptional signature of progesterone in the fathead minnow ovary (Pimephales promelas). Gen Comp Endocrinol 192:159-69
Kocerha, Jannet; Prucha, Melinda S; Kroll, Kevin J et al. (2010) Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways. Endocrinology 151:341-9
Tan, Xiaobing; Yim, Sun-Young; Uppu, Prasanna et al. (2010) Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate. Aquat Toxicol 99:300-8
Nyagode, Beatrice A; James, Margaret O; Kleinow, Kevin M (2009) Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108:320-9
Rauschenberger, R Heath; Sepulveda, Maria S; Wiebe, Jon J et al. (2009) Nutrient and organochlorine pesticide concentrations in American alligator eggs and their associations with clutch viability. J Aquat Anim Health 21:249-61

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