Abstract

(taken from applicant) ? ? This conference will elaborate on the importance and utility of the application of computational approaches using a systems biology approach to assess world-wide endocrine disruptions. This will include genomic sequencing (new models) database mining, genome wide expression analysis and molecular modeling. The audience will consist of comparative endocrinologist and this group will be equipped to evaluate and understand the corpus of information of animal cellular physiology in the context of environmental challenges and endocrine disruption in the natural biota of the world. Integration of this information with genomic data in turn will lead to a new animal models, which will inform human genomic/toxicological studies from a phylogenetic perspective. The venue is the XV International Conference of Comparative Endocrinology to be held in Boston May 23-28, 2005. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES007381-10S2
Application #
6943772
Study Section
Special Emphasis Panel (ZES1-SET-A (S7))
Program Officer
Thompson, Claudia L
Project Start
1997-04-01
Project End
2005-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
10
Fiscal Year
2004
Total Cost
$18,947
Indirect Cost

  Institution

Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Lille-Langøy, Roger; Karlsen, Odd André; Myklebust, Line Merethe et al. (2018) Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci :
Lemaire, Benjamin; Karchner, Sibel I; Goldstone, Jared V et al. (2018) Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta Proteins Proteom 1866:155-165
Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K et al. (2018) Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8:10404
Watt, James; Baker, Amelia H; Meeks, Brett et al. (2018) Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol 233:7007-7021
Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths: a case-control study from Massachusetts and Rhode Island. Environ Health 17:58
Kim, Stephanie; Li, Amy; Monti, Stefano et al. (2018) Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 92:2859-2874
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Timme-Laragy, Alicia R; Hahn, Mark E; Hansen, Jason M et al. (2018) Redox stress and signaling during vertebrate embryonic development: Regulation and responses. Semin Cell Dev Biol 80:17-28
Glazer, Lilah; Kido Soule, Melissa C; Longnecker, Krista et al. (2018) Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122
Basra, Komal; Scammell, Madeleine K; Benson, Eugene B et al. (2018) Ambient Air Exposure to PCBs: Regulation and Monitoring at Five Contaminated Sites in EPA Regions 1, 2, 4, and 5. New Solut 28:262-282

Showing the most recent 10 out of 398 publications