Abstract

(Taken from application) The Mount Sinai Superfund Basic Research Program Genetic Analysis Core, Core E, will carry out all nucleic acid based assays required for the biomedical Research Projects 10 and 3. The Core will extract and store coded human DNA samples for genotype analyses. Biallelic genotypes will be determined by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) or allele-specific PCR. Competing technologies may be substituted for cost reduction. The work of this Core will determine and characterize human polymorphisms known to affect lead metabolism [ALAD, VDR and HFE]. Also, the Core will examine polymorphisms affecting metabolism of organochlorines that may contribute gene-environment interactions potentially relevant to the genesis of Parkinson's Disease [CYP2D6, CYP2E1, PON1 and GSTP1, as well as known and newly-derived polymorphisms in PON2 and PON3]. Additional polymorphisms will be determined as requested by the Research Project Directors. The Core will determine mouse WNT4, WNT5a and WNT7a genotypes of progeny in crosses of knock-out mice in support of Research Project 9. The Core will search for human WNT polymorphisms for the three mouse WNT genes studied in Project 9. Human PON2 and PON3 will also be investigated. The Core will search for additional human polymorphisms as requested by the Directors of the Research Projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007384-06
Application #
6480313
Study Section
Special Emphasis Panel (ZES1)
Project Start
1995-05-01
Project End
2006-03-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Type
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Yan, Beizhan; Bopp, Richard F; Abrajano, Teofilo A et al. (2014) Source apportionment of polycyclic aromatic hydrocarbons (PAHs) into Central Park Lake, New York City, over a century of deposition. Environ Toxicol Chem 33:985-92
Miller, Todd R; Colquhoun, David R; Halden, Rolf U (2010) Identification of wastewater bacteria involved in the degradation of triclocarban and its non-chlorinated congener. J Hazard Mater 183:766-72
Miller, Todd R; Heidler, Jochen; Chillrud, Steven N et al. (2008) Fate of triclosan and evidence for reductive dechlorination of triclocarban in estuarine sediments. Environ Sci Technol 42:4570-6
Landrigan, Philip J; Forman, Joel; Galvez, Maida et al. (2008) Impact of September 11 World Trade Center disaster on children and pregnant women. Mt Sinai J Med 75:129-34
Louchouarn, Patrick; Chillrud, Steven N; Houel, Stephane et al. (2007) Elemental and molecular evidence of soot- and char-derived black carbon inputs to New York City's atmosphere during the 20th century. Environ Sci Technol 41:82-7
Wallenstein, Sylvan; Chen, Jia; Wetmur, James G (2006) Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Mol Genet Metab 89:270-3
Trasande, Leonardo; Schechter, Clyde; Haynes, Karla A et al. (2006) Applying cost analyses to drive policy that protects children: mercury as a case study. Ann N Y Acad Sci 1076:911-23
Ma, Risheng; Sassoon, David A (2006) PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract. Environ Health Perspect 114:898-904
Gobeille, Alayne K; Morland, Kimberly B; Bopp, Richard F et al. (2006) Body burdens of mercury in lower Hudson River area anglers. Environ Res 101:205-12
Trasande, Leonardo; Schechter, Clyde B; Haynes, Karla A et al. (2006) Mental retardation and prenatal methylmercury toxicity. Am J Ind Med 49:153-8

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