This is a Ph.D. training proposal. The primary aim is to train Ph.D. candidates in areas of biomedical and biological sciences relating to environmental toxicity, especially in areas relating to cellular signal transduction in mammalian cells, in areas that relate to activities in the labs of participating UCSD faculty members and in areas relating to the endeavors of several San Diego Corporate Partners in environmental sciences, screening and remediation.
The Aims of the training program are: a) to train graduate students in areas of signal transduction and modern cellular and molecular biology and associated techniques relating to environmental toxicity and its remediation, with a combination of laboratory and course work. b) to expose graduate students to research and daily activity in a environmental company or governmental regulatory agency. c) to provide a course in career alternatives, drawing on the San Diego industrial environmental community and on representatives of the EPA, such that students are scientifically prepared for careers in the environmental industry, in government, in private consulting, or in academia. d) to provide courses on regulatory and ethical issues that may be encountered by scientists working in the environmental industry. The training program combines core course work, lab rotations, grant/proposal writing, advanced courses and dissertation research. The core courses in the first year focus on cellular and molecular aspects of mammalian systems, including cell biology, molecular biology,, cellular and molecular pharmacology, systems physiology and statistical analysis. During the first year, students will also complete four 10 week lab rotations: two rotations with Program members, one rotation in the labs of a Corporate Partner and an additional laboratory experience in the San Diego Super Computer Center Working on the development and use of the Program's Geographic Information System (GIS) database on hazardous substances, water quality and public health of the San Diego- Tijuana (Mexico) border region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010337-02
Application #
6443975
Study Section
Special Emphasis Panel (ZES1)
Project Start
2001-04-01
Project End
2002-03-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$175,020
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306
Fan, Weiwei; He, Nanhai; Lin, Chun Shi et al. (2018) ERR? Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1?/?-Deficient Muscle. Cell Rep 22:2521-2529
Brouha, Sharon S; Nguyen, Phirum; Bettencourt, Ricki et al. (2018) Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: A prospective study. Eur Radiol 28:1345-1355
Hsu, Po-Kai; Takahashi, Yohei; Munemasa, Shintaro et al. (2018) Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980
Dhar, Debanjan; Antonucci, Laura; Nakagawa, Hayato et al. (2018) Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell 33:1061-1077.e6
Febbraio, Mark A; Reibe, Saskia; Shalapour, Shabnam et al. (2018) Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab :
Fujiwara, Ryoichi; Yoda, Emiko; Tukey, Robert H (2018) Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33:9-16
Hartmann, Phillipp; Hochrath, Katrin; Horvath, Angela et al. (2018) Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology 67:2150-2166
Ganguly, Abantika; Guo, Lan; Sun, Lingling et al. (2018) Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. PLoS Genet 14:e1007595
Tripathi, Anupriya; Debelius, Justine; Brenner, David A et al. (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411

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