The Outreach Core will implement a project that uses Geographic Information Systems spatial analysis of Superfund and TRI sites as well as chemical toxic equivalency data such as amount, persistence, and toxicity to categorize exposure hotspots in hour countries across North Carolina. The Outreach Core will overlay U.S. Census block group demographic data and birth certificate records on the Superfund and TRI data to identify potentially vulnerable populations. In particular, the inclusion of U.S. Census demographic factors will determine whether any particular group (i.e., socioeconomic, racial) is disproportionately represented in the exposure hotspots. Upon completion of the analysis, the Outreach Core will make the mappings available to state and county health departments as well as community based organizations along with summaries of relevant toxicological evidence. The combination of exposure data and explanation of the current evidence regarding the chemicals in question will allow public health professionals to better serve their clients while simultaneously empowering communities to self- advocate. The Superfund Outreach Core will focus on Beafort, Gaston, Moore, and Washington Counties in North Carolina. The county selections were based on a variety of characteristics including the presence of both Superfund and TRI sites, as well as the current or former presence of industries relating to chemical use, manufacture, or storage. Though an ongoing research project on low-level childhood lead exposure, members of the Outreach Core have established strong connections and working relationships with the State Health Director, as well as the Environmental Health Division within the state government. Additionally, Outreach Core staff have briefed the North Carolina Secretary of Health and the North Carolina General Assembly on children's special vulnerabilities to environmental toxicants. Through involvement with these groups, the Outreach Core has also established ties with many county health departments, health care providers, and community organizations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-02
Application #
6442564
Study Section
Special Emphasis Panel (ZES1)
Project Start
2001-04-01
Project End
2002-03-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$86,441
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Meyer, Joel N; Hartman, Jessica H; Mello, Danielle F (2018) Mitochondrial Toxicity. Toxicol Sci 162:15-23
Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30
Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2018) Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology 400-401:57-64
Lefèvre, Emilie; Bossa, Nathan; Gardner, Courtney M et al. (2018) Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110
Kollitz, Erin M; Kassotis, Christopher D; Hoffman, Kate et al. (2018) Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor ? Signaling. Environ Sci Technol :
Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359
Luz, Anthony L; Kassotis, Christopher D; Stapleton, Heather M et al. (2018) The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR? activation, in 3T3-L1 cells. Toxicology 393:150-159
Day, D B; Xiang, J; Mo, J et al. (2018) Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. Indoor Air 28:360-372
Slotkin, Theodore A; Ko, Ashley; Seidler, Frederic J (2018) Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? Toxicology 408:11-21
Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324

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