application) ? ? This workshop will bring together scientists and professionals from diverse fields including environmental toxicology and chemistry, biomedical toxicology, molecular biology, genetics, bioinformatics, computer science and statistics. Their purpose will be to discuss the current status of molecular approaches in their application to comparative biology as well as to identify opportunities to exploit molecular and computational approaches to improve our ability to select surrogate species for human and ecological risk assessment, including integrated assessment. In doing so, the participants will work towards further development of the science underlying human health-ecological integrity interconnections. The overall goal of this workshop is to outline a research agenda utilizing emerging technologies in omics (genomics, proteomics, and metabonomics) and computational biology (bioinformatics, statistics, modeling) in order to, 1) elucidate similarities and differences among species to stressors, and relate the responses to phenotype, 2) take advantage of omic approaches to develop interconnections between human health and ecological integrity paradigm, and 3) extend this science into innovative approaches to risk assessment and regulatory decision-making. All relevant discussions and conclusions from the workshop will be published in a book edited by Richard T. Di Giulio, and William H. Benson, and published through Society of Environmental Toxicology and Chemistry (SETAC) Press. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES010356-05S1
Application #
6868557
Study Section
Special Emphasis Panel (ZES1-SET-A (S1))
Program Officer
Thompson, Claudia L
Project Start
2000-06-01
Project End
2005-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
5
Fiscal Year
2004
Total Cost
$39,950
Indirect Cost
Name
Duke University
Department
Type
Schools of Earth Sciences/Natur
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Meyer, Joel N; Hartman, Jessica H; Mello, Danielle F (2018) Mitochondrial Toxicity. Toxicol Sci 162:15-23
Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30
Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2018) Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology 400-401:57-64
Lefèvre, Emilie; Bossa, Nathan; Gardner, Courtney M et al. (2018) Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110
Kollitz, Erin M; Kassotis, Christopher D; Hoffman, Kate et al. (2018) Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor ? Signaling. Environ Sci Technol :
Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359
Luz, Anthony L; Kassotis, Christopher D; Stapleton, Heather M et al. (2018) The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR? activation, in 3T3-L1 cells. Toxicology 393:150-159
Day, D B; Xiang, J; Mo, J et al. (2018) Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. Indoor Air 28:360-372
Slotkin, Theodore A; Ko, Ashley; Seidler, Frederic J (2018) Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? Toxicology 408:11-21
Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324

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