Abstract

The animal production core will provide selectively bred P and NP (alcohol-preferring and nonpreferring) lines of rats as well as the selectively bred HAD and LAD (high-alcohol-drinking and low-alcohol- drinking) rats for research. These animals are available to investigators supported by or affiliated with the ARC at this Institution and to collaborating and independent investigators at other Institutions. The Core will also continue the development of the P and NP inbred strains, begin inbreeding of the HAD and LAD lines after 15 generations of selection and correct the bleeding abnormality that has developed in the NP rats by backcrossing P x NP offspring to NP inbreds.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA007611-06
Application #
3767693
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Indiana University Bloomington
Department
Type
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401

  Publications

Houck, Christa A; Grahame, Nicholas J (2018) Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice. Psychopharmacology (Berl) 235:2167-2175
McClintick, Jeanette N; McBride, William J; Bell, Richard L et al. (2018) Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking. Alcohol 68:37-47
Ding, Zheng-Ming; Ingraham, Cynthia M; Hauser, Sheketha R et al. (2017) Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking. Alcohol Clin Exp Res 41:1896-1906
Linsenbardt, David N; Smoker, Michael P; Janetsian-Fritz, Sarine S et al. (2017) Impulsivity in rodents with a genetic predisposition for excessive alcohol consumption is associated with a lack of a prospective strategy. Cogn Affect Behav Neurosci 17:235-251
Bell, Richard L; Hauser, Sheketha R; Liang, Tiebing et al. (2017) Rat animal models for screening medications to treat alcohol use disorders. Neuropharmacology 122:201-243
Öztürk, Nail Can; Resendiz, Marisol; Öztürk, Hakan et al. (2017) DNA Methylation program in normal and alcohol-induced thinning cortex. Alcohol 60:135-147
Luczak, Susan E; Wall, Tamara L (2016) Gambling problems and comorbidity with alcohol use disorders in Chinese-, Korean-, and White-American college students. Am J Addict 25:195-202
Ding, Zheng-Ming; Ingraham, Cynthia M; Rodd, Zachary A et al. (2016) Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats. Neuropharmacology 109:41-48
Kasten, C R; Frazee, A M; Boehm 2nd, S L (2016) Developing a model of limited-access nicotine consumption in C57Bl/6J mice. Pharmacol Biochem Behav 148:28-37
Zhou, Feng C; Resendiz, Marisol; Lo, Chiao-Ling et al. (2016) Cell-Wide DNA De-Methylation and Re-Methylation of Purkinje Neurons in the Developing Cerebellum. PLoS One 11:e0162063

Showing the most recent 10 out of 253 publications