Abstract

The ability of alcohol (ethanol) to produce internal stimuli that direct appropriate behavior (i.e., discriminative stimuli) and maintain ethanol consumption (i.e., reinforcing stimuli) are fundamental processes postulated to be important for both normal drinking and excessive chronic alcohol use. However, how these ethanol stimulus effects are mediated within the central nervous system remains unclear. Work done by members of the proposed Center have elucidated several candidate neurobehavioral systems but a continued coordinated effort is needed to provide for the integration of the data from the molecular to the behavioral level of analysis. Using this already developed alcohol research team, the goals of the Center can be achieved.
The Specific Aims are: 1. Provide an integrated, multi-disciplinary approach to study ethanol's discriminative and reinforcing stimulus effects. 2. Provide a national resource for the dissemination of research findings and training in the area of neurobehavioral analysis of ethanol's stimulus effects related to alcohol abuse and alcoholism.
These aims are to be accomplished through the functions of an Administrative, Animal and Pilot Cores, and 5 projects which range from the molecular through the cellular to the behavioral levels of analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA011997-05
Application #
6626423
Study Section
Special Emphasis Panel (ZAA1-EE (02))
Program Officer
Grandison, Lindsey
Project Start
1999-01-01
Project End
2004-06-30
Budget Start
2003-01-15
Budget End
2004-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$1,511,749
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157

  Publications

Davenport, April T; Grant, Kathleen A; Szeliga, Kendall T et al. (2014) Standardized method for the harvest of nonhuman primate tissue optimized for multiple modes of analyses. Cell Tissue Bank 15:99-110
Freeman, Willard M; Vanguilder, Heather D; Guidone, Elizabeth et al. (2011) Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. Int J Neuropsychopharmacol 14:899-911
Lyn, Heidi; Pierre, Peter; Bennett, Allyson J et al. (2011) Planum temporale grey matter asymmetries in chimpanzees (Pan troglodytes), vervet (Chlorocebus aethiops sabaeus), rhesus (Macaca mulatta) and bonnet (Macaca radiata) monkeys. Neuropsychologia 49:2004-12
Graef, John D; Godwin, Dwayne W (2010) Intrinsic plasticity in acquired epilepsy: too much of a good thing? Neuroscientist 16:487-95
Freeman, Willard M; Salzberg, Anna C; Gonzales, Steven W et al. (2010) Classification of alcohol abuse by plasma protein biomarkers. Biol Psychiatry 68:219-22
Cheng, Heng-Jie; Grant, Kathleen A; Han, Qing-Hua et al. (2010) Up-regulation and functional effect of cardiac ?3-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res 34:1171-81
McCauley, Anita K; Frank, Steven T; Godwin, Dwayne W (2009) Brainstem nitrergic innervation of the mouse visual thalamus. Brain Res 1278:34-49
Shively, Carol A; Mietus, Joseph E; Grant, Kathleen A et al. (2007) Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis). Psychopharmacology (Berl) 192:183-91
Walker, Stephen J; Wang, Yulei; Grant, Kathleen A et al. (2006) Long versus short oligonucleotide microarrays for the study of gene expression in nonhuman primates. J Neurosci Methods 152:179-89
Freeman, Willard M; Gooch, Randy S; Lull, Melinda E et al. (2006) Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. Alcohol Alcohol 41:300-5

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