The goal of this competing continuation request is to examine the role of genetic and family environmental influences, and their interaction, in the development and course of alcohol use disorders (AUD). This is to be achieved using a research strategy that incorporates 3 novel features: (a) use of the infrequently implemented yet powerful children of twins (COT) design involving twins who are concordant or discordant for-AUD as well as control pairs; (b) assessment of children of alcoholic mothers; (c) use of a prospective design which allows for the description of offspring development from preadolescence through the late twenties. The COT design is particularly well suited for studying environmental variables associated with maternal alcoholism in that statistical controls for genetic influences are embedded within the design, providing the opportunity to isolate environmental variables that are etiologically relevant to the development of alcohol problems. It is also well suited for detecting the contribution of genetic transmission to the association between AUDs in parents, and other disorders in offspring (e.g. Attention Deficit Hyperactivity Disorder, ADHD), as well as potential genotype x environment interaction effects. The assessment of twin mothers will fill an important research need in the field and will allow for comparisons with our MARC-affiliated studies involving the same design but based on twin fathers. Finally, our longitudinal, prospective design will allow us to make much stronger statements concerning the development of AUD than would be possible using only retrospective data from a cross-sectional study. During the renewal period, we will continue to expand our recruitment efforts, broadening our eligibility criteria to include mothers with offspring as young as 7 years. In so doing we will be able to confirm or disconfirm our emerging data based on retrospective reports of twin mothers about their adolescent and young adult offspring on disorders with early childhood onset (ADHD, Oppositional Defiant Disorder [ODD], conduct disorder [CD]). We will continue follow-up assessments by maternal interview (offspring aged 9-18) and offspring interview (aged 11-30). By the end of the renewal period, samples will be sufficiently large so that complex cross-sectional and longitudinal analyses will be firmly based.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA011998-06
Application #
6967376
Study Section
Special Emphasis Panel (ZAA1-AA (06))
Project Start
2004-06-01
Project End
2009-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
6
Fiscal Year
2004
Total Cost
$232,718
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Marceau, Kristine; Cinnamon Bidwell, L; Karoly, Hollis C et al. (2018) Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype. J Abnorm Child Psychol 46:685-699
Colodro-Conde, L; Sánchez-Romera, J F; Lind, P A et al. (2018) No evidence of association of oxytocin polymorphisms with breastfeeding in 2 independent samples. Genes Brain Behav 17:e12464
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14:277-283
Aslinger, Elizabeth N; Manuck, Stephen B; Pilkonis, Paul A et al. (2018) Narcissist or narcissistic? Evaluation of the latent structure of narcissistic personality disorder. J Abnorm Psychol 127:496-502
Trela, Constantine J; Hayes, Alexander W; Bartholow, Bruce D et al. (2018) Moderation of alcohol craving reactivity to drinking-related contexts by individual differences in alcohol sensitivity: An ecological investigation. Exp Clin Psychopharmacol 26:354-365
Whitfield, John B; Heath, Andrew C; Madden, Pamela A F et al. (2018) Effects of high alcohol intake, alcohol-related symptoms and smoking on mortality. Addiction 113:158-166
Wang, Frances L; Chassin, Laurie (2018) Negative Urgency Mediates the Relation between Genetically-Influenced Serotonin Functioning and Alcohol Problems. Clin Psychol Sci 6:106-122
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Sartor, Carolyn E; Grant, Julia D; Few, Lauren R et al. (2018) Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. Prev Sci 19:795-804

Showing the most recent 10 out of 368 publications