Abstract

The Biostatistics Core has four major responsibilities: 1) to provide statistical design and analysis consultation services to ADRC investigators; 2) to prepare the ADRC database for submission to the Alzheimer's Disease Data Coordinating Center; 3) to coordinate the entry, quality control and management of data generated by the Clinical and Neuropathology cores; and 4) to educate investigators trainees and junior facility in the principles and use of statistical analysis methodologies. Statistical consultation ranges from power analysis and the conduct of complex multivariate modeling. Data management and information distribution will be facilitated by the continued development of high-e4nd relational database systems accessible through a private Intranet.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005131-19
Application #
6589273
Study Section
Project Start
2002-05-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
19
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Saberi, Shahram; Stauffer, Jennifer E; Jiang, Jie et al. (2018) Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol 135:459-474
Lee, Ming-Hsiang; Siddoway, Benjamin; Kaeser, Gwendolyn E et al. (2018) Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature 563:639-645
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Chen, Xu-Qiao; Fang, Fang; Florio, Jazmin B et al. (2018) T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic 19:840-853
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Sundermann, Erin E; Tran, My; Maki, Pauline M et al. (2018) Sex differences in the association between apolipoprotein E ?4 allele and Alzheimer's disease markers. Alzheimers Dement (Amst) 10:438-447

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