The principal objective of the Clinical Core will be to recruit and maintain a panel of approximately 400 volunteer patients and controls at the ADRC, and 100 volunteer patients and controls as part of our Hispanic initiative at our satellite clinic in Chula Vista. The Core will recruit new subjects with a diagnosis of Mild Cognitive Impairment (MCI) and very early AD (MMSE greater than or equal to 20) to replace subjects who have become more impaired. A pool of 40 subjects will be maintained with DRS scores greater than or equal to 109 to meet the needs of our research protocols. During this competitive renewal cycle we will specifically increase our pool of MCI subject to 100 for Dr. Bondi's project on functional MRI. Particular emphasis will continue to be placed on the recruitment of normal controls over the age of 80, in order to meet the need for greater numbers of autopsied brains for clinical-pathotogical correlations and biochemical studies. Annual participant evaluations will include demographic, history, medical neurological, psychiatric, and neuropsychological examinations to aid in the diagnosis and to track yearly changes in cognitive and neurological progression. The evaluations provide a behavioral database that can be used by the various research projects associated with the ADRC and in addition provide longitudinal data on the course and progression of AD. The Clinical Core maintains banks of DNA, plasma, serum, and CSF, used by various UCSD investigators and collaborators at other institutions and in industry. The Clinical Core provides the resources for participation in a variety of multi-center clinical trials and collaborative studies using both subjects and data. Finally developmental work will be undertaken to improve our ability to diagnose early AD and to improve the diagnosis of other dementias such as dementia with Lewy bodies and fronto-temporal dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
2P50AG005131-21
Application #
6797553
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J5))
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
21
Fiscal Year
2004
Total Cost
$1,015,846
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Chen, Xu-Qiao; Fang, Fang; Florio, Jazmin B et al. (2018) T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic 19:840-853
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Sundermann, Erin E; Tran, My; Maki, Pauline M et al. (2018) Sex differences in the association between apolipoprotein E ?4 allele and Alzheimer's disease markers. Alzheimers Dement (Amst) 10:438-447
Edmonds, Emily C; Weigand, Alexandra J; Thomas, Kelsey R et al. (2018) Increasing Inaccuracy of Self-Reported Subjective Cognitive Complaints Over 24 Months in Empirically Derived Subtypes of Mild Cognitive Impairment. J Int Neuropsychol Soc 24:842-853
Graves, Lisa V; Van Etten, Emily J; Holden, Heather M et al. (2018) Refining CVLT-II recognition discriminability indices to enhance the characterization of recognition memory changes in healthy aging. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 25:767-782

Showing the most recent 10 out of 914 publications