Abstract

Core G: Neurogenetics Abstract The Neurogenetics Core builds on the strengths of genetics of dementia at the University of Pittsburgh. Genetics studies as part of the University of Pittsburgh Alzheimer's Disease Research Center (PITT-ADRC) were started by Dr. Kamboh (Core Leader) in 1995 when we initiated blood collection and APOE genotyping on all participants of the PITT-ADRC. In addition to collecting blood samples from PITT- ADRC participants, we collect blood samples from ADRC and non-ADRC ancillary studies that provide additional well-characterized older controls essential for genetic association studies and endophenotype data that would help to identify novel genes for dementia. The resources built by the PITT-ADRC Neurogenetics Core have contributed to the identification of several new genes for AD and also have served as an educational and training hub for graduate students and junior faculty at the University of Pittsburgh. The goal of the PITT-ADRC Neurogenetics Core is to continue collecting and archiving DNA and blood samples from new and existing AD patients and controls in order to enlarge our case-control and family sample and to augment the amount of existing DNA that would be critical to future efforts in identifying new genes/variants for AD. DNA and genotype (APOE and new risk markers) data will be provided to investigators upon request.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005133-35
Application #
9462783
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Snitz, Beth E; Wang, Tianxiu; Cloonan, Yona Keich et al. (2018) Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. Alzheimers Dement 14:734-742
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Fowler, Nicole R; Shaaban, C Elizabeth; Torke, Alexia M et al. (2018) ""I'm Not Sure We Had A Choice"": Decision Quality and The Use of Cardiac Implantable Electronic Devices In Older Adults With Cognitive Impairment. Cardiol Cardiovasc Med 2:10-26
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Karim, Helmet T; Wang, Maxwell; Andreescu, Carmen et al. (2018) Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin 19:831-839
Kamboh, M Ilyas (2018) A Brief Synopsis on the Genetics of Alzheimer's Disease. Curr Genet Med Rep 6:133-135
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064

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