The Massachusetts Alzheimer's Disease Research Center (ADRC) is a multi-institutional consortium composed of Harvard-affiliated facilities including the Massachusetts General Hospital, the Brigham and Women's Hospital, the Harvard Division on Aging and the Hebrew Rehabilitation Center for the Aged. The broad goals of the Massachusetts ADRC have evolved from those first proposed in 1984 but remain constant in the mission to prevent, cure or at least treat effectively AD and related dementing diseases. The specific goals are: To propose and support new research in neuroscience directed toward uncovering the etiology and pathogenetic mechanisms of AD and related dementias; to enhance collaborative dementia research funded outside of the ADRC; and to catalyze education, training and information transfer related to AD and related dementias. To accomplish these goals, we will retain the four Core facilities that were established 20 years ago. Investigators in the Clinical Core examine and diagnose patients with AD and related disorders, and refer them for participation in specific research Projects. The purpose of the Neuropathology Core is to establish diagnoses on all brains submitted to the Tissue Resource Center, store fixed and frozen brain tissue and distribute brain tissue to qualified investigators. The Education and Information Transfer Core has developed programs to train future leaders in academic fields related to aging and dementia, to educate caregivers, and to enroll elderly, non-demented control subjects into ADRC research. To these four Cores, we have added a fifth: The Data Management and Statistics Core that will carry on and expand activities that had previously been housed in the Administrative Core. The overriding mission of the ADRC is to stimulate and support research of the highest quality. This application contains three R01-type Projects that are closely inter-related and also tightly linked to the Clinical, Neuropathological and Data Management and Statistics Cores.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005134-24S1
Application #
7481748
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J4))
Program Officer
Phelps, Creighton H
Project Start
1997-04-01
Project End
2009-03-31
Budget Start
2007-08-15
Budget End
2008-03-31
Support Year
24
Fiscal Year
2007
Total Cost
$126,000
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Lee, Christopher M; Jacobs, Heidi I L; Marquié, Marta et al. (2018) 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis 62:1691-1702
Eftekharzadeh, Bahareh; Daigle, J Gavin; Kapinos, Larisa E et al. (2018) Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron 99:925-940.e7
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Emerson, Sarah C; Waikar, Sushrut S; Fuentes, Claudio et al. (2018) Biomarker validation with an imperfect reference: Issues and bounds. Stat Methods Med Res 27:2933-2945
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Pasi, Marco; Marini, Sandro; Morotti, Andrea et al. (2018) Cerebellar Hematoma Location: Implications for the Underlying Microangiopathy. Stroke 49:207-210
Hopp, Sarah C; Lin, Yang; Oakley, Derek et al. (2018) The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. J Neuroinflammation 15:269
Xiong, Li; van Veluw, Susanne J; Bounemia, Narimene et al. (2018) Cerebral Cortical Microinfarcts on Magnetic Resonance Imaging and Their Association With Cognition in Cerebral Amyloid Angiopathy. Stroke 49:2330-2336
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325

Showing the most recent 10 out of 966 publications