Abstract

The specific aims are: To establish an accurate neuropathological diagnosis on all brains submitted to the ADRC Tissue Resource Center; To submit a standardized report, clinicopathological correlation and interpretation of findings to the Clinical Core; To prepare tissues in a standardized manner for use by qualified investigators in the Massachusetts ADRC and other investigators in the field of AD; To prepare tissue microarrays representing distinct groups of diseases or anatomical areas for use by investigators in the ADRC; To establish the degree of RNA preservation in the tissues stored in the Bank; To maintain the Tissue Resource Center as a source of brain tissue for investigators studying AD; To develop and enlarge upon cooperative ventures with the Udall Parkinson Center at the MGH and the Harvard Center for Neurodegeneration; To facilitate correlative studies (including NACC) of pathology with clinical, behavioral, anatomic, genetic, imaging and neurochemical aspects of AD; and To provide a resource for the training and education of future investigators in the neuroanatomy and neuropathology of dementing disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005134-25
Application #
7596944
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
25
Fiscal Year
2008
Total Cost
$335,643
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Jacobs, Heidi I L; Hedden, Trey; Schultz, Aaron P et al. (2018) Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci 21:424-431
Rieckmann, Anna; Johnson, Keith A; Sperling, Reisa A et al. (2018) Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging. Proc Natl Acad Sci U S A 115:10160-10165
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Martinez-Ramirez, Sergi; van Rooden, Sanneke; Charidimou, Andreas et al. (2018) Perivascular Spaces Volume in Sporadic and Hereditary (Dutch-Type) Cerebral Amyloid Angiopathy. Stroke 49:1913-1919
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Putcha, Deepti; McGinnis, Scott M; Brickhouse, Michael et al. (2018) Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy. Cortex 106:36-46
Qian, Jing; Chiou, Sy Han; Maye, Jacqueline E et al. (2018) Threshold regression to accommodate a censored covariate. Biometrics :
Mordes, Daniel A; Prudencio, Mercedes; Goodman, Lindsey D et al. (2018) Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun 6:55
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Makaretz, Sara J; Quimby, Megan; Collins, Jessica et al. (2018) Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. J Neurol Neurosurg Psychiatry 89:1024-1031

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