Abstract

This application constitutes the fourth competitive renewal of the Mount Sinai School of Medicine Alzheimer's Disease Research Center. Its fundamental goals have not change since the first funding period, however it has expanded much since then. In this renewal the following cores and projects are propose: . Clinical Research Support Core/El hurst Satellite (D. Marin) . Information Transfer Core (R. Mohs) . Neuropathology Core (D. Perl) . Project: """"""""Molecular Genetic Studies of Neurofilament Assembly and Function"""""""" (R. Lazzarini) . Project: """"""""Quantitative Indices of Neuron Vulnerability in Dementia"""""""" (P. Hof) . Project: """"""""Novel Presenilin Binding Proteins"""""""" (J. Buxbaum) . Project: """"""""Vascular Localization and Function of Presenilin 1 Fragments (N. Robakis) . Project: """"""""An alpha2 Agonist and Cholinesterase Inhibitor in AD"""""""" . Project: """"""""Risk Factors in Very Late Onset AD"""""""" (J. Silverman)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005138-20S4
Application #
6952621
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
1984-09-28
Project End
2005-03-31
Budget Start
2004-09-30
Budget End
2005-03-31
Support Year
20
Fiscal Year
2004
Total Cost
$2,000
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Kinnunen, Kirsi M; Cash, David M; Poole, Teresa et al. (2018) Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study. Alzheimers Dement 14:43-53
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Moreno, Cesar L; Della Guardia, Lucio; Shnyder, Valeria et al. (2018) iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling. Mol Neurodegener 13:33
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Toker, Lilah; Mancarci, Burak Ogan; Tripathy, Shreejoy et al. (2018) Transcriptomic Evidence for Alterations in Astrocytes and Parvalbumin Interneurons in Subjects With Bipolar Disorder and Schizophrenia. Biol Psychiatry 84:787-796
Gandal, Michael J; Haney, Jillian R; Parikshak, Neelroop N et al. (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693-697
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642

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