Abstract

This ADRC consortium represents more than 100 faculty-level Participating Investigators with major interests in Alzheimer disease and the neurobiology of aging. Most studies are performed in facilities for basic and clinical research at the University of Southern California (USC) and the University of California at Irvine (UCI). Basic research emphasizes molecular mechanisms in neurodegeneration. Clinical research emphasizes new diagnostics and interventions for AD victims and their care-givers. Besides the required Cores [Administrative, Clinical, Neuropathology, and Research Training and Information Transfer Cores], we have Cores for Genetic Epidemiology, Pharmacology, and a Satellite at Cal State Los Angels (CSLA). A new Neuro-imaging Core is proposed. Program at CSLA and in other Cores address minorities that are under-represented in research on Alzheimer's disease, in order to increase access of the victims to new diagnoses and treatments, as well as to reduce the burden of care-givers. A common database is being constructed through the Teradata relational database computer at UCI that will be accessible to researchers throughout this ADRC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
2P50AG005142-11
Application #
2048977
Study Section
Special Emphasis Panel (ZAG1-MJF-2 (01))
Project Start
1984-09-28
Project End
1999-03-31
Budget Start
1994-05-01
Budget End
1995-03-31
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Miscellaneous
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Petok, Jessica R; Myers, Catherine E; Pa, Judy et al. (2018) Impairment of memory generalization in preclinical autosomal dominant Alzheimer's disease mutation carriers. Neurobiol Aging 65:149-157
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Weissberger, Gali H; Nation, Daniel A; Nguyen, Caroline P et al. (2018) Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans. Neurosci Biobehav Rev 94:49-58
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Wang, Junyan; Aydogan, Dogu Baran; Varma, Rohit et al. (2018) Modeling topographic regularity in structural brain connectivity with application to tractogram filtering. Neuroimage 183:87-98

Showing the most recent 10 out of 590 publications