This ADRC consortium represents more than 100 faculty-level Participating Investigators with major interests in Alzheimer disease and the neurobiology of aging. Most studies are performed in facilities for basic and clinical research at the University of Southern California (USC) and the University of California at Irvine (UCI). Basic research emphasizes molecular mechanisms in neurodegeneration. Clinical research emphasizes new diagnostics and interventions for AD victims and their care-givers. Besides the required Cores [Administrative, Clinical, Neuropathology, and Research Training and Information Transfer Cores], we have Cores for Genetic Epidemiology, Pharmacology, and a Satellite at Cal State Los Angels (CSLA). A new Neuro-imaging Core is proposed. Program at CSLA and in other Cores address minorities that are under-represented in research on Alzheimer's disease, in order to increase access of the victims to new diagnoses and treatments, as well as to reduce the burden of care-givers. A common database is being constructed through the Teradata relational database computer at UCI that will be accessible to researchers throughout this ADRC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-12
Application #
2048980
Study Section
Special Emphasis Panel (ZAG1-MJF-2 (01))
Project Start
1984-09-28
Project End
1999-03-31
Budget Start
1995-04-15
Budget End
1996-03-31
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Southern California
Department
Miscellaneous
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Hernandez, Gerson; Zhao, Liqin; Franke, Adrian A et al. (2018) Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor ?-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause 25:191-196
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Ho, Jean K; Nation, Daniel A; Alzheimer’s Disease Neuroimaging Initiative (2018) Neuropsychological Profiles and Trajectories in Preclinical Alzheimer's Disease. J Int Neuropsychol Soc 24:693-702
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826

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