Abstract

The Latino population is an under-studied group in relation to epidemiological studies of cognitive impairment and dementia [Valle, 1994 #1103]. Utilizing the resources from our one-year ADRC supplement, we have incorporated a cognitive screening instrument (CASI-S) into an existing cohort study in Latino adults residing in La Puente, California (Supplement to NIA P50 AG05142). Our long-term objectives are to establish a cognitive component within this cohort to estimate incidence and prevalence of cognitive impairment and dementia in this Latino population, and to use identified incident cases for population-based epidemiological studies, with particular interest in vascular risk factors and dementia. Our short-term objectives for this one-year proposal (4-1-03 to 3-31-04) relate to methodological evaluation of our cognitive screening instrument in this Latino population and to establish feasibility for intensive cognitive follow-up. These research activities are essential steps to support future plans for a long-term cognitive follow-up study. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005142-20S3
Application #
6599032
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Phelps, Creighton H
Project Start
1998-04-01
Project End
2004-03-31
Budget Start
2003-09-01
Budget End
2004-03-31
Support Year
20
Fiscal Year
2003
Total Cost
$186,936
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Hernandez, Gerson; Zhao, Liqin; Franke, Adrian A et al. (2018) Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor ?-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause 25:191-196
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Ho, Jean K; Nation, Daniel A; Alzheimer’s Disease Neuroimaging Initiative (2018) Neuropsychological Profiles and Trajectories in Preclinical Alzheimer's Disease. J Int Neuropsychol Soc 24:693-702
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826

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