The overall objectives of the Neuropathology Core are to support AD research studies by supplying thoroughly evaluated brain and other tissues from Alzheimer's disease (AD) patients and normal control subjects to investigators.
The specific aims of the Neuropathology Core will be to a) perform short postmortem interval autopsies of AD and control subjects and distribute brain tissue to investigators of the Alzheimer Disease Research Center (ADRC) and other AD projects b) describe the extent and distribution of neuropathologic abnormalities and provide the diagnoses of autopsied AD and control subjects for participants in the ADRC and other AD projects, c) correlate the neuropsychologic and clinical data with the neuropathologic findings in AD subjects, d) correlate the neuropsychologic and clinical data with the neuropathologic features in control subjects with emphasis on those with early cognitive decline to determine the neuropathologic features of this group, e) provide appropriate family members of autopsied AD and control subjects with a prompt written report of the neuropathologic findings and diagnoses, and f) maintain a brain bank of CSF blood, brain, and other organs stored at - 70 degreesC and fixed brain tissue from autopsied AD and control subjects for investigators in the ADRC and other AD related projects in this and other institutions. Sections from brain regions immediately adjacent to those used for research studies will be evaluated for histopathologic abnormalities to allow for morphologic correlations with specific research parameters. Standard histologic stains and immunohistochemical reactions will be utilized for diagnoses and quantitation of senile plaques and neurofibrillary tangles. In addition, the Core will perform clinico- pathologic correlative studies on brains of autopsied subjects. The Neuropathology Core also will perform diagnostic studies on the autopsied brains from a large cohort of 670 Catholic sisters (Nuns) who are being evaluated prospectively and who have volunteered for brain donation. The Core also supports two other AD Program Project Grants and several R0-1 AD-related grants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005144-16
Application #
6295411
Study Section
Project Start
1999-05-04
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Broster, Lucas S; Li, Juan; Wagner, Benjamin et al. (2018) Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex. J Clin Exp Neuropsychol 40:761-776
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Reed, Rebecca G; Greenberg, Richard N; Segerstrom, Suzanne C (2017) Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: The moderating effect of beta blockade. Brain Behav Immun 61:14-20
Li, Juan; Broster, Lucas S; Jicha, Gregory A et al. (2017) A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging. Alzheimers Res Ther 9:3
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Wei, Shaoceng; Kryscio, Richard J (2016) Semi-Markov models for interval censored transient cognitive states with back transitions and a competing risk. Stat Methods Med Res 25:2909-2924

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