Abstract

The Washington University ADRC has been functioning since 1985. Emphasis on the work of the Center has focused on interdisciplinary longitudinal clinical analysis of dementia of the Alzheimer's type and the study of clinicopathologic correlates, with emphasis on distinguishing the earliest symptoms of AD. The ADRC performs and provides logistical and material support for research projects and this and many other institutes. It also provides for a range of informational and training activities aimed at both the professional and lay communities. To execute these activities the ADRC consists the ADRC consists of five Cores, Administrative, Clinical, Biostatistics, Neuropathology and Tissue Resource, and Training and Information Transfer (TITC). Two Satellites are supported by the Center. An African American Outreach Satellite of the Clinical Core designed to provide services to the African American Community in St. Louis and to increase the participation. of these subjects in the research activities of the Clinical Core. The Missouri/Iowa Satellite of TITC is designed to provide informational services to the rural populations of the states and the physicians and other health professionals that serve them Four research projects will be carried out using genetic, cell biological, biochemical, and neuroimaging, technologies to address fundamental mechanisms of the pathogenesis of Alzheimer's disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005681-20S2
Application #
6836843
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
1985-09-30
Project End
2005-04-30
Budget Start
2004-01-01
Budget End
2004-04-30
Support Year
20
Fiscal Year
2004
Total Cost
$60,461
Indirect Cost

  Institution

Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Musiek, Erik S; Bhimasani, Meghana; Zangrilli, Margaret A et al. (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol 75:582-590
Yan, Qi; Nho, Kwangsik; Del-Aguila, Jorge L et al. (2018) Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging. Mol Psychiatry :
Babulal, Ganesh M; Chen, Suzie; Williams, Monique M et al. (2018) Depression and Alzheimer's Disease Biomarkers Predict Driving Decline. J Alzheimers Dis 66:1213-1221
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Broce, Iris; Karch, Celeste M; Wen, Natalie et al. (2018) Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med 15:e1002487
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Gangishetti, Umesh; Christina Howell, J; Perrin, Richard J et al. (2018) Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease. Alzheimers Res Ther 10:98
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Strain, Jeremy F; Smith, Robert X; Beaumont, Helen et al. (2018) Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions. Neurology 91:e313-e318
Roe, Catherine M; Babulal, Ganesh M; Stout, Sarah H et al. (2018) Using the A/T/N Framework to Examine Driving in Preclinical AD. Geriatrics (Basel) 3:

Showing the most recent 10 out of 952 publications