Abstract

Clinical criteria can identify elderly individuals with mild cognitive impairment (MCI). Although MCI is enriched with subjects who have pre-dementia Alzheimer's disease (AD), MCI is clinically heterogeneous. Alzheimer's disease begins in the entorhinal cortex, and imaging entorhinal integrity enhances our ability to detect AD among MCI subjects. MRI can assess entorhinal integrity using two approaches: The first approach relies on structural images to measure entorhinal volume;while the second MRI approach relies on hemodynamic images to estimate entorhinal metabolism. Among different hemodynamic variables, MRI measures of cerebral blood volume (CBV) have proven capable to detect AD-related metabolic dysfunction, including entorhinal dysfunction. The primary goal of this proposal is to determine which MRI measure of entorhinal integrity best detects pre-dementia AD?entorhinal volume, entorhinal metabolism, or perhaps both in combination. In order to achieve this goal we will measure entorhinal volume and entorhinal CBV in a single group of individuals with MCI. We will follow subjects until progression to dementia, and identify which measure of entorhinal integrity best predicts progression to AD. An ancillary goal of this proposal is to follow subjects until autopsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008702-20
Application #
7858432
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
20
Fiscal Year
2009
Total Cost
$212,223
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064

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