This proposal aims to renew our established Alzheimer's Disease Research Center (ADRC) at the University of California at Irvine (UCI). The ADRC will focus on the basic cellular and molecular mechanisms of brain aging and Alzheimer's disease (AD), seek to identify mechanisms of early pathogenic change and relate these mechanisms to cognitive and behavioral functions. Building upon the existing UCI Institute for Brain Aging and Dementia, a strong group of investigators including many new faculty, and continuing commitments by UCI, the ADRC will offer an opportunity to link pioneering basic research into early cellular and molecular mechanisms of AD to clinical applications, and apply clinical insights to basic research. The ADRC will bring several themes to AD research: first are basic and clinical studies on brain plasticity and compensation - particularly learning and memory, second, a cutting-edge basic science perspective on the mechanisms of neurodegeneration with a commitment to link basic and clinical studies, and third, a new initiative to study clinical, neuropsychological and neuropathological characteristics of the oldest-old (90+ year-olds). The three ADRC Projects are directed at investigating mechanisms hypothesized to contribute to early aging and AD progression. Project 1 focuses on neural correlates of episodic memory in subjects including the oldest-old using cognitive tasks and functional brain imaging. Projects 2 and 3 focus on cellular and molecular mechanisms. Many investigators recognize two candidate mechanisms associated with the pathogenesis of AD: 1) mitochondria! Dysfunction and oxidative damage 2) beta-amyloid accumulation, and neurofibrillary tangle formation. Accordingly, one Project is directed at understanding mitochondria! variations and somatic mutations while the other is devoted to the application of immunotherapy to reduce tau aggregates and tangles. As its long-term goal, the UCI-ADRC will strive to incorporate the latest in modern neurosciences and cognitive neurosciences to elucidate the nature of molecular and cellular dysfunction mediated behavioral changes. The proposed ADRC infrastructure will support the Projects and over 30 other faculty investigators in the ADRC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016573-10
Application #
7596956
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J4))
Program Officer
Phelps, Creighton H
Project Start
2000-05-15
Project End
2010-03-31
Budget Start
2009-06-01
Budget End
2010-03-31
Support Year
10
Fiscal Year
2009
Total Cost
$1,822,270
Indirect Cost
Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Cox, Chelsea G; Ryan B A, Mary M; Gillen, Daniel L et al. (2018) A Preliminary Study of Clinical Trial Enrollment Decisions Among People With Mild Cognitive Impairment and Their Study Partners. Am J Geriatr Psychiatry :
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Agrawal, Sudhanshu; Abud, Edsel M; Snigdha, Shikha et al. (2018) IgM response against amyloid-beta in aging: a potential peripheral protective mechanism. Alzheimers Res Ther 10:81
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307

Showing the most recent 10 out of 518 publications