Abstract

The NIA guidelines for non-mandatory cores state: """"""""the NIA, through the ADRC, will support additional cores that provide opportunities for scientific accomplishments beyond those attainable solely through support of the mandatory cores"""""""".
The Aims of the Neuroimaging Core of this ADRC grant meet these criteria. Each of the 4 Aims proposed delineates a general area of pertinent research which will be facilitated by the activities of the Neuroimaging Core.
In Aim #1 the Neuroimaging ore will provide research support to the Clinical Core.
In Aims #2 -#4, the activities of the Core are of a developmental nature with the objective of applying three promising new MRI technologies to the study of aging and AD.
Four Specific Aims are proposed:
Specific Aim #1 : To provide quantitative MRI measurements in the Jacksonville minority population study.
Specific Aim #2 : To apply a new MR technique developed at Mayo--magnetic resonance elastography--to studies of aging and AD.
Specific Aim #3 : To apply new techniques for MRI motion correction to studies of aging and AD.
Specific Aim #4 : To apply high field (3 Tesla) MRI to studies of aging and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016574-01S2
Application #
6098847
Study Section
Project Start
1999-08-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Vemuri, Prashanthi; Lesnick, Timothy G; Przybelski, Scott A et al. (2018) Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging. Ann Neurol 84:705-716
Eftekharzadeh, Bahareh; Daigle, J Gavin; Kapinos, Larisa E et al. (2018) Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron 99:925-940.e7
Lowe, Val J; Lundt, Emily S; Senjem, Matthew L et al. (2018) White Matter Reference Region in PET Studies of 11C-Pittsburgh Compound B Uptake: Effects of Age and Amyloid-? Deposition. J Nucl Med 59:1583-1589
Zhao, Na; Liu, Chia-Chen; Van Ingelgom, Alexandra J et al. (2018) APOE ?2 is associated with increased tau pathology in primary tauopathy. Nat Commun 9:4388
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Vassilaki, Maria; Aakre, Jeremiah A; Syrjanen, Jeremy A et al. (2018) Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis 64:281-290
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325

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