Abstract

The NIA guidelines for non-mandatory cores state: """"""""the NIA, through the ADRC, will support additional cores that provide opportunities for scientific accomplishments beyond those attainable solely through support of the mandatory cores"""""""".
The Aims of the Neuroimaging Core of this ADRC grant meet these criteria. Each of the 4 Aims proposed delineates a general area of pertinent research which will be facilitated by the activities of the Neuroimaging Core.
In Aim #1 the Neuroimaging ore will provide research support to the Clinical Core.
In Aims #2 -#4, the activities of the Core are of a developmental nature with the objective of applying three promising new MRI technologies to the study of aging and AD.
Four Specific Aims are proposed:
Specific Aim #1 : To provide quantitative MRI measurements in the Jacksonville minority population study.
Specific Aim #2 : To apply a new MR technique developed at Mayo--magnetic resonance elastography--to studies of aging and AD.
Specific Aim #3 : To apply new techniques for MRI motion correction to studies of aging and AD.
Specific Aim #4 : To apply high field (3 Tesla) MRI to studies of aging and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016574-01S3
Application #
6395482
Study Section
Project Start
1999-08-15
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Kasanuki, Koji; Ross, Owen A; DeTure, Michael A et al. (2018) Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs. Mov Disord 33:333-334
Tachibana, Masaya; Yamazaki, Yu; Liu, Chia-Chen et al. (2018) Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-? pathology in amyloid model mice. Exp Neurol 300:13-21
Guerreiro, Rita; Ross, Owen A; Kun-Rodrigues, Celia et al. (2018) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol 17:64-74
Deelchand, Dinesh K; Kantarci, Kejal; Öz, Gülin (2018) Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting. Magn Reson Med 79:1241-1250
Levendowski, Daniel J; St Louis, Erik K; Strambi, Luigi Ferini et al. (2018) Comparison of EMG power during sleep from the submental and frontalis muscles. Nat Sci Sleep 10:431-437
Whitwell, Jennifer L; Graff-Radford, Jonathan; Tosakulwong, Nirubol et al. (2018) [18 F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease. Ann Neurol 83:248-257
Allen, Mariet; Wang, Xue; Burgess, Jeremy D et al. (2018) Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimers Dement 14:352-366
Stricker, Nikki H; Lundt, Emily S; Edwards, Kelly K et al. (2018) Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: assessing cross-modality equivalence of computerized neuropsychological tests. Clin Neuropsychol :1-25
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Bove, Riley M; Patrick, Ellis; Aubin, Cristin McCabe et al. (2018) Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex. PLoS One 13:e0199073

Showing the most recent 10 out of 1014 publications