Abstract

The NIA guidelines for non-mandatory cores state: """"""""the NIA, through the ADRC, will support additional cores that provide opportunities for scientific accomplishments beyond those attainable solely through support of the mandatory cores"""""""".
The Aims of the Neuroimaging Core of this ADRC grant meet these criteria. Each of the 4 Aims proposed delineates a general area of pertinent research which will be facilitated by the activities of the Neuroimaging Core.
In Aim #1 the Neuroimaging ore will provide research support to the Clinical Core.
In Aims #2 -#4, the activities of the Core are of a developmental nature with the objective of applying three promising new MRI technologies to the study of aging and AD.
Four Specific Aims are proposed:
Specific Aim #1 : To provide quantitative MRI measurements in the Jacksonville minority population study.
Specific Aim #2 : To apply a new MR technique developed at Mayo--magnetic resonance elastography--to studies of aging and AD.
Specific Aim #3 : To apply new techniques for MRI motion correction to studies of aging and AD.
Specific Aim #4 : To apply high field (3 Tesla) MRI to studies of aging and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016574-01S4
Application #
6396650
Study Section
Project Start
1999-09-30
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Baker, Darren J; Petersen, Ronald C (2018) Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives. J Clin Invest 128:1208-1216
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Ramanan, Vijay K; Przybelski, Scott A; Graff-Radford, Jonathan et al. (2018) Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. J Alzheimers Dis 65:1345-1352
Knopman, David S; Lundt, Emily S; Therneau, Terry M et al. (2018) Joint associations of ?-amyloidosis and cortical thickness with cognition. Neurobiol Aging 65:121-131
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Ferman, Tanis J; Aoki, Naoya; Crook, Julia E et al. (2018) The limbic and neocortical contribution of ?-synuclein, tau, and amyloid ? to disease duration in dementia with Lewy bodies. Alzheimers Dement 14:330-339
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358

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