Abstract

The NIA guidelines for non-mandatory cores state: """"""""the NIA, through the ADRC, will support additional cores that provide opportunities for scientific accomplishments beyond those attainable solely through support of the mandatory cores"""""""".
The Aims of the Neuroimaging Core of this ADRC grant meet these criteria. Each of the 4 Aims proposed delineates a general area of pertinent research which will be facilitated by the activities of the Neuroimaging Core.
In Aim #1 the Neuroimaging ore will provide research support to the Clinical Core.
In Aims #2 -#4, the activities of the Core are of a developmental nature with the objective of applying three promising new MRI technologies to the study of aging and AD.
Four Specific Aims are proposed:
Specific Aim #1 : To provide quantitative MRI measurements in the Jacksonville minority population study.
Specific Aim #2 : To apply a new MR technique developed at Mayo--magnetic resonance elastography--to studies of aging and AD.
Specific Aim #3 : To apply new techniques for MRI motion correction to studies of aging and AD.
Specific Aim #4 : To apply high field (3 Tesla) MRI to studies of aging and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016574-01S4
Application #
6396650
Study Section
Project Start
1999-09-30
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Allen, Mariet; Wang, Xue; Burgess, Jeremy D et al. (2018) Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimers Dement 14:352-366
Stricker, Nikki H; Lundt, Emily S; Edwards, Kelly K et al. (2018) Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: assessing cross-modality equivalence of computerized neuropsychological tests. Clin Neuropsychol :1-25
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Bove, Riley M; Patrick, Ellis; Aubin, Cristin McCabe et al. (2018) Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex. PLoS One 13:e0199073
La Joie, Renaud; Ayakta, Nagehan; Seeley, William W et al. (2018) Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement :
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Sun, Wenyan; Samimi, Hanie; Gamez, Maria et al. (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci 21:1038-1048
Zhao, Na; Liu, Chia-Chen; Qiao, Wenhui et al. (2018) Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. Biol Psychiatry 83:347-357
Graff-Radford, Jonathan; Rabinstein, Alejandro A; Lesnick, Timothy G et al. (2018) Microinfarcts and blood pressure trajectories: response to Dr Niu et al. J Hum Hypertens 32:385

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