The Biostatistics and Database Management Core will provide database and statistical support to the Mayo Alzheimer's Disease Research Center (ADRC) Projects and Cores. To this end, our specific aims are:
Specific Aim 1. To develop and maintain a relational database housing the longitudinal clinical and neuropsychometric data gathered by the Clinical Core.
Specific Aim 2. To provide database support and biostatistical consulting support to the Projects and Cores. Building upon the existing Mayo ADRC relational database structure, database management staff will expand the Clinical Core psychometric and clinical exam database to accommodate new forms introduced by the Clinical Core and new forms mandated by the NIA (the expanded standard clinical data set). Various improvements to our database will be implemented, including a web-based data element dictionary and electronic data audit capabilities. The Clinical Core database will be linked to imaging, genotype, neuropathology, and DNA and plasma inventory databases, and data management staff will support data requests by Core and Project investigators. Biostatisticians will support Core and Project investigators in study design, analysis, and interpretation. The Biostatistics and Database Management Core will provide database support and dedicated time for statistical consulting to all of the Cores and Projects. Sharing of database and statistical personnel will allow us to efficiently support various projects and ensure that biostatistical consultants familiar with Alzheimer's disease and with the details of the Mayo Clinic ADRC are available to Cores and Projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016574-10
Application #
7618222
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
10
Fiscal Year
2008
Total Cost
$171,555
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Vassilaki, Maria; Aakre, Jeremiah A; Syrjanen, Jeremy A et al. (2018) Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis 64:281-290
Zhao, Na; Liu, Chia-Chen; Van Ingelgom, Alexandra J et al. (2018) APOE ?2 is associated with increased tau pathology in primary tauopathy. Nat Commun 9:4388
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Mordes, Daniel A; Prudencio, Mercedes; Goodman, Lindsey D et al. (2018) Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun 6:55
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Zhan, Yiqiang; Clements, Mark S; Roberts, Rosebud O et al. (2018) Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies. Neurobiol Aging 69:111-116
Lowe, Val J; Bruinsma, Tyler J; Min, Hoon-Ki et al. (2018) Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants. Alzheimers Dement (Amst) 10:210-216
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Sassi, Celeste; Nalls, Michael A; Ridge, Perry G et al. (2018) Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiol Aging 66:179.e17-179.e29
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021

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