Core D. The Neuropathology Core performs diagnostic evaluations and quantitative analyses on brain tissue collected at autopsy of participants in the Mayo Alzheimer Disease Research Center (ADRC) and related projects, in particular the Alzheimer Disease Patient Registry (ADPR). The Core also provides support to research projects of the ADRC and to other investigators at the Mayo Clinic. The neuropathology data is communicated to the Biostatistics Core and to the National Alzheimer Coordinating Center (NACC).
The specific aims of the NP Coreare: 1. Perform brain autopsies on participants of the Mayo ADRC in a timely fashion and according to protocol. 2. Provide neuropathologic evaluations and collect neuropathologic data using standardized methods for gross dissection and neurohistologic staining. a. Cooperate with neuroradiology in the acquisition of post-mortem MRI scans of hemi-brains. b. Dissect brains according to a standardized protocol, and photograph all sections. Score the severity of cerebrovascular pathology, and measure and sample macroscopic lesions. c. Use histological methods, including silver stains and immunohistochemistry for tau and Ap to collect standardized pathologic data on all cases. d. Perform immunostaining with antibodies to a-synuclein on all cases. In cases with Lewy bodies, assign a diagnosis according to the Consortium for Dementia with Lewy Bodies. e. Perform immunostaining with antibodies to TDP-43 on all cases, and when positive on the screening section, subtype and map the distribution of TDP-43 pathology. f. Consensus on clinicopathologic diagnoses are made at videoconferences held twice a month. g. Provide neuropathological data to the National Alzheimer Coordinating Center (NACC). 3. Store brain tissue and brain derived material (e.g., DNA) and provide clinically and pathologically well- characterized tissue samples, DNA or data to investigators of ADRC research projects and ADRC pilot projects as well as to qualified outside investigators.
The Neuropathology Core provides a final diagnosis (the""""""""gold standard"""""""") for the patients enrolled in the study and is a repository of data and tissue for research purposes. Neuropathologic studies provide quality control and advance understanding of human neurologic disorders with the goals of improving diagnostic accuracy and understanding the cause of these disorders.
| Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872 |
| Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064 |
| Jack Jr, Clifford R; Wiste, Heather J; Schwarz, Christopher G et al. (2018) Longitudinal tau PET in ageing and Alzheimer's disease. Brain 141:1517-1528 |
| Jung, Youngsin; Jordan 3rd, Lennon G; Lowe, Val J et al. (2018) Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia. Ann Clin Transl Neurol 5:376-381 |
| Townley, Ryan A; Botha, Hugo; Graff-Radford, Jonathan et al. (2018) 18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus. Neuroimage Clin 18:897-902 |
| Kidana, Kiwami; Tatebe, Takuya; Ito, Kaori et al. (2018) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med 10: |
| Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43 |
| Arnold Fiebelkorn, Catherine; Vemuri, Prashanthi; Rabinstein, Alejandro A et al. (2018) Frequency of Acute and Subacute Infarcts in a Population-Based Study. Mayo Clin Proc 93:300-306 |
| Baker, Darren J; Petersen, Ronald C (2018) Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives. J Clin Invest 128:1208-1216 |
| Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10 |
Showing the most recent 10 out of 1014 publications
