Abstract

CORE F - ABSTRACT This is a proposal to renew the Imaging Core for the UCSF Alzheimer's Disease Research Center (ADRC). The Imaging Core has supported the UCSF ADRC for nearly 10 years by managing acquisition, archiving and processing of high quality structural and functional MRI and PET datasets, and providing these data to ADRC and other investigators. In the coming cycle the Core will pursue the following aims: 1. Collection and archiving of MP-RAGE, FLAIR, T2-weighted, DTI, ASL perfusion, ICN-fMRI, and [18F]Florbetapir PET images, and maintenance of an image database. 2. Preprocessing of MP-RAGE images to correct for scanner-related artifacts and performing integrated image pre-processing for DW-MRI, ASL-MRI, ICN-fMRI, and PET images. 3. Extraction and uploading of data to common database, including processing and editing of T1-weighted images with FreeSurfer (FS) and production of cortical thickness measures and gray and white matter volumes for standard cortical and subcortical regions, and regional perfusion, and normalized amyloid tracer binding values for standard ROIs in FS space. 4. Enhancement of FS-based image processing by creation of disease-specific templates to serve as targets in FS for morphing new research images into standardized space and identifying gray and white matter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG023501-15
Application #
9472245
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
15
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Vatsavayai, Sarat C; Nana, Alissa L; Yokoyama, Jennifer S et al. (2018) C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies. Acta Neuropathol :
Hua, Alice Y; Sible, Isabel J; Perry, David C et al. (2018) Enhanced Positive Emotional Reactivity Undermines Empathy in Behavioral Variant Frontotemporal Dementia. Front Neurol 9:402
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Miller, Zachary A; Rosenberg, Lynne; Santos-Santos, Miguel A et al. (2018) Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. JAMA Neurol 75:728-737
Ossenkoppele, Rik; Rabinovici, Gil D; Smith, Ruben et al. (2018) Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA 320:1151-1162
Rojas, Julio C; Stephens, Melanie L; Rabinovici, Gil D et al. (2018) Multiproteinopathy, neurodegeneration and old age: a case study. Neurocase 24:1-6
Mandelli, Maria Luisa; Welch, Ariane E; Vilaplana, Eduard et al. (2018) Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA. Cortex 108:252-264
Zylstra, Bradley; Netscher, George; Jacquemot, Julien et al. (2018) Extended, continuous measures of functional status in community dwelling persons with Alzheimer's and related dementia: Infrastructure, performance, tradeoffs, preliminary data, and promise. J Neurosci Methods 300:59-67
Pressman, Peter S; Shdo, Suzanne; Simpson, Michaela et al. (2018) Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease. Front Neurol 9:464

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