Abstract

The mission of the Wisconsin Alzheimer's Disease Research Center (ADRC) Data Management and Biostatistics Core (Core C) is to promote excellence by providing outstanding data management, biomedical computing, and biostatistical support to Wisconsin ADRC investigators and affiliates. To accomplish this objective, Core C has the following specific aims:
Specific Aim 1 : To provide and maintain quality protocol and data management for projects affiliated with the Wisconsin ADRC;
Specific Aim 2 : To provide a biomedical computing infrastructure and services for projects affiliated with the Wisconsin ADRC;
Specific Aim 3 : To provide comprehensive statistical support (including study design, implementation, data analysis, and methodology development) to all projects associated with the Wisconsin ADRC;
Specific Aim 4 : To work with the NACC to create a smooth and efficient exchange of data and to collaborate with other ADRCs, ADCCs, and AD researchers;
Specific Aim 5 : To interface effectively with each of the other Wisconsin ADRC Cores to provide comprehensive, high-quality support to achieve the overall mission of the ADRC. The proposed specific aims will utilize and solidify existing resources to ensure an effective ADRC that will support cutting-edge clinical, basic, and translational research on a cohort at risk for AD (i.e., WRAP), as well as those with MCI, AD and related neurodegenerative disorders. These resources include extensive existing collaborations, financial commitments, data sources and acknowledged excellence in data management, an existing state-wide network, advanced informatics capabilities, and acknowledged expertise in biostatistics and informatics

Public Health Relevance

The Data Management and Biostatistics Core will provide critical support for the Wisconsin ADRC to accomplish its objectives targeting one of the most common and devastating neurodegenerative illnesses known to afflict humans. Given the projected exponential increase in the number of Americans likely to be affected by AD, it is pivotal that novel treatment and prevention strategies be identified. The Wisconsin ADRC will help accomplish this national priority.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG033514-04
Application #
8377722
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$204,768
Indirect Cost
$66,878

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Holden, Timothy R; Keller, Sarah; Kim, Alice et al. (2018) Procedural Framework to Facilitate Hospital-Based Informed Consent for Dementia Research. J Am Geriatr Soc 66:2243-2248
Betthauser, Tobey J; Cody, Karly A; Zammit, Matthew D et al. (2018) In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer's disease dementia to young controls. J Nucl Med :
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Hao, Ling; Wang, Jingxin; Page, David et al. (2018) Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer's Disease. Sci Rep 8:9291
Bettcher, Brianne M; Johnson, Sterling C; Fitch, Ryan et al. (2018) Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage. J Alzheimers Dis 62:385-397
Mueller, Kimberly D; Koscik, Rebecca L; Clark, Lindsay R et al. (2018) The Latent Structure and Test-Retest Stability of Connected Language Measures in the Wisconsin Registry for Alzheimer's Prevention (WRAP). Arch Clin Neuropsychol 33:993-1005
Zhou, Hao Henry; Singh, Vikas; Johnson, Sterling C et al. (2018) Statistical tests and identifiability conditions for pooling and analyzing multisite datasets. Proc Natl Acad Sci U S A 115:1481-1486
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360

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