Abstract

The Center for Interdisciplinary Research in Immunologic Diseases (CIRID at UCLA) includes two distinctive but interrelated themes supported by three Core resources. Each of the themes has several components: Disease Immunopathogenesis and Immune Interventions includes investigations of CD4 and CD8 T cells, B cells, NK cells and monocytes. Diseases included are: inflammatory bowel diseases (Role of in vivo primed CTL in immune disorders), common variable immunodeficiency and bone marrow transplantation (Retinoids/lymphokines enhance defective human B cells), AIDS (B cell stimulating factors in AIDS and HIV infection) and (Monocyte function in pediatric AIDS), neonatal development and recovery following bone marrow transplantation (Differentiation of CD8+ cytotoxic/suppressor cells) and other immune disorders (Immunologic effects of lymphokine therapies). Behavioral and Educational Interventions in Immunological Diseases and AIDS includes asthma (Pre-School Asthma Care Training: The Asthma Bear Care Program) and (Asthma Self Care for Latino children and parents), AIDS (prevention of AIDS among black and Latina women) and Outreach, Education and Demonstration Programs for community and national outreach, AIDS educational programs for health care professionals (physicians and nurses) and increased patient participation in care of inflammatory bowel disease. These are supported by Core services including an Immune Function Laboratory, a Flow Cytometry Laboratory, and an Administration and Biostatistics Core. The CIRID program at UCLA also benefits from cooperation which additional faculty in the Schools of Medicine, Public Health, Nursing and the College of Letters and Sciences. CIRID Outreach acts as a catalyst for programs within UCLA and in the community. CIRID programs serve to utilize the resources of both to achieve optimal efforts in relation to asthma, allergies, AIDS, immune deficiency disorders and other immunologic diseases. With this broad scope of activities and resources, CIRID at UCLA functions as a NIAID-sponsored Immunologic Diseases Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
2P50AI015332-11
Application #
3104995
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Project Start
1978-09-01
Project End
1993-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Flaskerud, J H; Anderson, N (1999) Disseminating the results of participant-focused research. J Transcult Nurs 10:340-9
Flaskerud, J H; Nyamathi, A M; Uman, G C (1997) Longitudinal effects of an HIV testing and counseling programme for low-income Latina women. Ethn Health 2:89-103
Storek, J; Witherspoon, R P; Webb, D et al. (1996) Lack of B cells precursors in marrow transplant recipients with chronic graft-versus-host disease. Am J Hematol 52:82-9
Flaskerud, J H; Uman, G (1996) Acculturation and its effects on self-esteem among immigrant Latina women. Behav Med 22:123-33
Flaskerud, J H; Nyamathi, A M (1996) Home medication injection among Latina women in Los Angeles: implications for health education and prevention. AIDS Care 8:95-102
Iseki, M; Ank, B J; Stiehm, E R (1994) Peripheral immunoglobulin secreting cells in immunodeficiencies;effects of intravenous immune globulin. Ann Allergy 72:419-24
Roberts, R L; Ank, B J; Stiehm, E R (1994) Antiviral properties of neonatal and adult human neutrophils. Pediatr Res 36:792-8
Mulligan, M J; Stiehm, E R (1994) Neonatal hepatitis B infection: clinical and immunologic considerations. J Perinatol 14:2-9
Storek, J; Hultin, L E; Ferrara, S et al. (1994) B cell dysfunction after bone marrow transplantation is associated with decreased Ca2+ flux upon membrane Ig crosslinking. Clin Immunol Immunopathol 72:210-6
Hofmann, B; Nishanian, P; Nguyen, T et al. (1993) Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues. AIDS 7:659-64

Showing the most recent 10 out of 141 publications