Abstract

This program project proposes to study immunopathogenesis in atopic bronchial asthma with particular emphasis on late phase responses in man and a rabbit model. Changes in specific antibodies of the various immunoglobulin isotypes, relationships of IgA and IgE to the mucus layer, and activation of complement components will be evaluated. Differences between symptomatic and asymptomatic atopic individuals, as well as between atopic and nonatopic individuals, will be studied using longitudinal followup, humoral and cellular responses to specific allergen, and bronchoprovocation. Selected individuals will receive bronchoalveolar lavage for studies of humoral and cellular immunologic parameters in the pulmonary compartment in bronchial asthma. Rabbit models of preferential IgE production will be correlated with longitudinal studies in man including responses to immunotherapeutic maneuvers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI019093-03
Application #
3105035
Study Section
Allergy and Immunology Research Committee (AIRC)
Project Start
1983-09-30
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1987-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Fuortes, L J; Weih, L; Pomrehn, P et al. (1997) Prospective epidemiologic evaluation of laboratory animal allergy among university employees. Am J Ind Med 32:665-9
Fuortes, L J; Weih, L; Jones, M L et al. (1996) Epidemiologic assessment of laboratory animal allergy among university employees. Am J Ind Med 29:67-74
Muller, B A; Leick, C A; Suelzer, M et al. (1994) Prognostic value of methacholine challenge in patients with respiratory symptoms. J Allergy Clin Immunol 94:77-87
Muller, B A; Leick, C A; Smith, R M et al. (1993) Comparisons of specific and nonspecific bronchoprovocation in subjects with asthma, rhinitis, and healthy subjects. J Allergy Clin Immunol 91:758-72
Casale, T B (1993) Acute effects of in vitro mast cell degranulation on human lung muscarinic receptors. Am Rev Respir Dis 147:940-5
Casale, T B; Abbas, M K; Carolan, E J (1992) Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. Am J Respir Cell Mol Biol 7:112-7
Little, M M; Casale, T B (1991) Comparison of platelet-activating factor-induced chemotaxis of normodense and hypodense eosinophils. J Allergy Clin Immunol 88:187-92
Casale, T B; Abbas, M K (1991) Effects of various barriers on platelet-activating factor-induced neutrophil chemotaxis. J Allergy Clin Immunol 87:565-74
Cavanah, D K; Casale, T B (1991) Cutaneous responses to anticholinergics: evidence for muscarinic receptor subtype participation. J Allergy Clin Immunol 87:971-6
Casale, T B (1991) Neuropeptides and the lung. J Allergy Clin Immunol 88:1-14

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