Abstract

This Asthma and Allergic Diseases Center application, made up of four independent but interrelated projects, proposes to study immunopathogenesis of atopic bronchial asthma, with particular attention to interactions between local inflammatory processes secondary to inhalational allergen challenge, nonspecific bronchial hyperresponsiveness, clinical manifestations of disease and response to treatment. Local changes in cells, antibodies and mediators will be studied longitudinally using the technique of bronchoalveolar lavage. Chopped fresh human lung obtained at thoracotomy for surgical indications will be studied for alterations in beta adrenergic and cholinergic receptors following in vitro anaphylaxis. Longitudinal assessment of laboratory animal workers will evaluate the epidemiology of allergic responsiveness among those newly exposed to atopic allergens, and similar studies will evaluate the development of IgE, IgG and IgA antibodies in individuals newly exposed to ragweed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
3P50AI019093-08S1
Application #
3105034
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1983-09-30
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1994-08-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Fuortes, L J; Weih, L; Pomrehn, P et al. (1997) Prospective epidemiologic evaluation of laboratory animal allergy among university employees. Am J Ind Med 32:665-9
Fuortes, L J; Weih, L; Jones, M L et al. (1996) Epidemiologic assessment of laboratory animal allergy among university employees. Am J Ind Med 29:67-74
Muller, B A; Leick, C A; Suelzer, M et al. (1994) Prognostic value of methacholine challenge in patients with respiratory symptoms. J Allergy Clin Immunol 94:77-87
Muller, B A; Leick, C A; Smith, R M et al. (1993) Comparisons of specific and nonspecific bronchoprovocation in subjects with asthma, rhinitis, and healthy subjects. J Allergy Clin Immunol 91:758-72
Casale, T B (1993) Acute effects of in vitro mast cell degranulation on human lung muscarinic receptors. Am Rev Respir Dis 147:940-5
Casale, T B; Abbas, M K; Carolan, E J (1992) Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. Am J Respir Cell Mol Biol 7:112-7
Casale, T B; Abbas, M K (1991) Effects of various barriers on platelet-activating factor-induced neutrophil chemotaxis. J Allergy Clin Immunol 87:565-74
Cavanah, D K; Casale, T B (1991) Cutaneous responses to anticholinergics: evidence for muscarinic receptor subtype participation. J Allergy Clin Immunol 87:971-6
Casale, T B (1991) Neuropeptides and the lung. J Allergy Clin Immunol 88:1-14
Little, M M; Casale, T B (1991) Comparison of platelet-activating factor-induced chemotaxis of normodense and hypodense eosinophils. J Allergy Clin Immunol 88:187-92

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