Abstract

Continuation of support is requested for a multidisciplinary center to study the basic pathologic mechanisms of certain skin diseases which appear to have the participation of humoral or cellular immunologic events, either as a primary or secondary manifestation. The center will concentrate in studies of: 1. Diseases within the spectrum of cutaneous vasculitis-angioedema-urticaria. In these studies we will attempt to identify the biochemical mediators and cellular interactions that may be responsible for the clinical manifestations in this group of diseases. 2. Receptors in patients presenting with clinical manifestations within the spectrum of altered immunologic reactivity. These studies will involve patients with: acquired deficiency syndrome, lupus erythematosus and Hansen's disease. It is proposed that complement receptors may be predictive markers of disease activity. 3. Phototoxic reactions either due to genetic defects in phorphyrin metabolism or intake of medications. These diseases offer an excellent model for studies of non-immunologic activation of the complement system and mast cell derived mediators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI020476-07
Application #
3105058
Study Section
(SRC)
Project Start
1983-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Oh, Sera; Han, A Rheum; Park, Hye Ryeon et al. (2014) Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis. Chem Biodivers 11:1034-41
Barrett, K E; Yen, A; Bigby, T D et al. (1994) Inhibition of human peripheral blood lymphocyte function by protoporphyrin and longwave ultraviolet light. J Immunol 153:3286-94
Barrett, K E; Bigby, T D (1993) Involvement of arachidonic acid in the chloride secretory response of intestinal epithelial cells. Am J Physiol 264:C446-52
Yen, A; Liu, F T; Barrett, K E et al. (1993) Alterations in Fc epsilon RI induced by protoporphyrin plus long-wavelength ultraviolet light in mouse bone marrow-derived mast cells. J Immunol 151:1003-11
Dovezenski, N; Billetta, R; Gigli, I (1992) Expression and localization of proteins of the complement system in human skin. J Clin Invest 90:2000-12
Broide, D H; Lotz, M; Cuomo, A J et al. (1992) Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 89:958-67
Yen, A; Barrett, K E; Gigli, I (1992) Protoporphyrin and long-wave ultraviolet light modulate metabolic events in rat peritoneal mast cells. J Invest Dermatol 98:488-93
Yen, A; Traynor-Kaplan, A E; Barrett, K E et al. (1991) The ability of protoporphyrin plus long-wave ultraviolet light to inhibit calcium mobilization and mediator release in mast cells is not related to changes in phospholipid signaling pathways. Trans Assoc Am Physicians 104:194-205
Yen, A; Gigli, I; Barrett, K E (1991) Modulation of human cutaneous mast cell responsiveness by a single, low-dose, PUVA treatment. J Allergy Clin Immunol 88:395-401
Barrett, K E (1991) Immune-related intestinal chloride secretion. III. Acute and chronic effects of mast cell mediators on chloride secretion by a human colonic epithelial cell line. J Immunol 147:959-64

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