The Bihar Tropical Medicine Research Center will unite a multi-national group of investigators studying critical aspects of human infection with the protozoan Leishmania donovani in an endemic region of northern India. Projects will focus on the clinical and epidemiological aspects of visceral leishmaniasis (project 1), human immune responses during progressive disease (project 2) and genetic factors governing susceptibility to infection (project 3). Subjects and data/specimen collection will be done through project 1, which will provide material for analyses done in all three projects. A data management core will be set up to support the three projects in the Bihar State Tropical Medicine Research Center. Westat will initiate the data entry and management systems, and set up means to interface with analytical statistical methods required for each of the three projects. Currently, most data collection, transfer and analysis at BHU sites is done by hard copy paper forms, which are entered into Microsoft Excel or Access databases prior to data analysis. These methods have limited security, and they do not allow for an audit trail. 1. The primary aim of the Data Management Core is to establish data management capacity at Banaras Hindu University (BHU) and its associated field site in order to successfully manage the data generated in the three TMRC projects as well as clinical and epidemiological research studies that BHU is planning to carry out in the future. 2. The secondary aims are to establish electronic data management systems that are secure and leave an audit trail, and to develop operations manuals as well as SOPs for data management. 3. The systems will provide support that will facilitate statistical analyses of epidemiologic, immunologic, and genetics data, but also for immunological data collected as part of the research projects.
We aim to initiate a system that will support not only the current proposed projects, but also set up a site that will be poised for future studies of vaccine candidates and therapeutic interventions in this fatal disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI074321-02
Application #
7673884
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
2
Fiscal Year
2008
Total Cost
$92,161
Indirect Cost
Name
Banaras Hindu University
Department
Type
DUNS #
650330558
City
Varanasi
State
Country
India
Zip Code
22100-5
Sundar, Shyam; Singh, Anup (2018) Chemotherapeutics of visceral leishmaniasis: present and future developments. Parasitology 145:481-489
Sundar, Shyam; Singh, Bhawana (2018) Emerging therapeutic targets for treatment of leishmaniasis. Expert Opin Ther Targets 22:467-486
Sundar, Shyam; Singh, Bhawana (2018) Understanding Leishmania parasites through proteomics and implications for the clinic. Expert Rev Proteomics 15:371-390
Sundar, Shyam; Agarwal, Dipti (2018) Visceral Leishmaniasis-Optimum Treatment Options in Children. Pediatr Infect Dis J 37:492-494
Singh, Neetu; Sundar, Shyam (2018) Combined neutralization of interferon gamma and tumor necrosis factor alpha induces IL-4 production but has no direct additive impact on parasite burden in splenic cultures of human visceral leishmaniasis. PLoS One 13:e0199817
Singh, Neetu; Kumar, Rajiv; Chauhan, Shashi Bhushan et al. (2018) Peripheral Blood Monocytes With an Antiinflammatory Phenotype Display Limited Phagocytosis and Oxidative Burst in Patients With Visceral Leishmaniasis. J Infect Dis 218:1130-1141
Singh, Toolika; Fakiola, Michaela; Oommen, Joyce et al. (2018) Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis. J Immunol 200:2727-2737
Kelly, Patrick H; Bahr, Sarah M; Serafim, Tiago D et al. (2017) The Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum. MBio 8:
Sharma, Smriti; Srivastva, Shweta; Davis, Richard E et al. (2017) The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis. Am J Trop Med Hyg 97:767-770
Kansal, S; Chakravarty, J; Kumar, A et al. (2017) Risk Factors associated with defaulting from visceral leishmaniasis treatment: analysis under routine programme conditions in Bihar, India. Trop Med Int Health 22:1037-1042

Showing the most recent 10 out of 90 publications